Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT02199665
Age 18 +
Sex Both
Phase Phase 1
Third Opinion Trial Synopsis
This study is looking at a new treatment for multiple myeloma, a type of cancer that doesn't respond well to treatment or has come back after treatment. The doctors will use three drugs called selinexor, carfilzomib, and dexamethasone to try and stop the cancer from growing. The drugs work in different ways to kill the cancer cells or stop them from dividing. The doctors want to find out the best way to use these drugs together and what side effects they might cause.
This study is looking at a new treatment for multiple myeloma, a type of cancer that doesn't respond well to treatment or has come back after treatment. The doctors will use three drugs called selinexor, carfilzomib, and dexamethasone to try and stop the cancer from growing. The drugs work in different ways to kill the cancer cells or stop them from dividing. The doctors want to find out the best way to use these drugs together and what side effects they might cause.
Third Opinion AI Generated Synopsis
Trial Summary
This phase I trial studies the side effects and best dose of selinexor and carfilzomib when given together with dexamethasone in treating patients with multiple myeloma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as selinexor and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving selinexor, carfilzomib, and dexamethasone may be a better treatment for multiple myeloma.
This phase I trial studies the side effects and best dose of selinexor and carfilzomib when given together with dexamethasone in treating patients with multiple myeloma that has returned or does not respond to treatment. Drugs used in chemotherapy, such as selinexor and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving selinexor, carfilzomib, and dexamethasone may be a better treatment for multiple myeloma.
from ClinicalTrials.gov
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