Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma
NCT04640779
Age 18 +
Sex Both
Phase Phase 1
Third Opinion Trial Synopsis
This study is testing the effects of choline salicylate and selinexor together on patients with certain types of cancer. Choline salicylate is a medicine that helps lower the immune system's response and is used along with other drugs to treat cancer. Selinexor works by stopping cancer cells from growing. This trial will help doctors learn more about how these drugs can treat lymphoma, myeloma, and other types of cancer.
This study is testing the effects of choline salicylate and selinexor together on patients with certain types of cancer. Choline salicylate is a medicine that helps lower the immune system's response and is used along with other drugs to treat cancer. Selinexor works by stopping cancer cells from growing. This trial will help doctors learn more about how these drugs can treat lymphoma, myeloma, and other types of cancer.
Third Opinion AI Generated Synopsis
Trial Summary
This phase Ib trial evaluates the side effects and best dose of choline salicylate given together with a low dose of selinexor in treating patients with non-Hodgkin or Hodgkin lymphoma, or multiple myeloma whose prior treatment did not help their cancer (refractory) or for patients with histiocytic/dendritic cell neoplasm. Anti-inflammatory drugs, such as choline salicylate lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Selinexor may stop the growth of cancer cells by blocking a protein called CRM1 that is needed for cell growth. This trial may help doctors learn more about selinexor and choline salicylate as a treatment for with non-Hodgkin or Hodgkin lymphoma, histiocytic/dendritic cell neoplasm, multiple myeloma.
This phase Ib trial evaluates the side effects and best dose of choline salicylate given together with a low dose of selinexor in treating patients with non-Hodgkin or Hodgkin lymphoma, or multiple myeloma whose prior treatment did not help their cancer (refractory) or for patients with histiocytic/dendritic cell neoplasm. Anti-inflammatory drugs, such as choline salicylate lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Selinexor may stop the growth of cancer cells by blocking a protein called CRM1 that is needed for cell growth. This trial may help doctors learn more about selinexor and choline salicylate as a treatment for with non-Hodgkin or Hodgkin lymphoma, histiocytic/dendritic cell neoplasm, multiple myeloma.
from ClinicalTrials.gov
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