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Cervino: Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06158841
Age Range: 18+
Sex: ALL
Phase: 3

Cervino is a Phase 3 trial for patients with relapsed or refractory multiple myeloma who have received 2 or more prior therapies and have not received a treatment that targets BCMA. The goal of the study is to compare the effectiveness and safety of the investigational BCMA-targeting bispecific antibody, etentamig, to standard treatment options.

A Study of Dabrafenib and/or Trametinib in Patients With Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT03091257
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing the cancer drugs Dabrafenib and Trametinib in patients with multiple myeloma that has returned or stopped responding to previous treatments and contains specific genetic mutations (BRAF, KRAS, or NRAS). This research is unique because it targets specific genetic changes found in the cancer cells, which may help doctors provide more personalized treatment options for Multiple Myeloma patients whose disease has these particular mutations.
Third Opinion AI Generated Synopsis

Phase II Study of Salvage Radiation Treatment After B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy for Relapsed Refractory Multiple Myeloma

NCT ID: NCT05336383
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing radiation therapy as a follow-up treatment for patients with relapsed or refractory multiple myeloma whose cancer has returned or progressed after receiving CAR-T cell therapy (a type of immunotherapy that uses modified immune cells). This approach is unique because it specifically targets myeloma tumors that remain active after CAR-T treatment, potentially offering patients an additional treatment option that may help control their cancer and extend the time before further progression occurs.
Third Opinion AI Generated Synopsis

Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

NCT ID: NCT04959175
Age Range: 12 - 85
Sex: ALL
Phase: 1, 2
This study tests whether using a lower dose of cyclophosphamide (a chemotherapy drug) after bone marrow transplant can reduce side effects while still preventing graft-versus-host disease in older patients or those unfit for standard high-dose treatment who have blood cancers like multiple myeloma. The research aims to make transplants safer for patients who cannot tolerate intensive treatment by finding the right balance between effectiveness and reduced toxicity.
Third Opinion AI Generated Synopsis

The Talisman Study: A Study to Evaluate Preventive Treatments for Talquetamab-related Oral Toxicity

NCT ID: NCT06500884
Age Range: 18+
Sex: ALL
Phase: 2

The phase 2 TALISMAN study is evaluating how to manage oral side effects from Talquetamab, a bispecific antibody treatment. The study is recruiting participants in the United States with relapsed or refractory multiple myeloma and there are over 8 sites currently open.

A Study of Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants With High-Risk Multiple Myeloma

NCT ID: NCT06550895
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing the combination of Cilta-cel (a CAR-T cell therapy) and Talquetamab (an immunotherapy drug) in patients with high-risk multiple myeloma who have received at least three prior treatments. This research is unique because it combines two advanced immunotherapy approaches that work together to help the patient's immune system fight cancer cells more effectively than either treatment alone.
Third Opinion AI Generated Synopsis

Safety, Efficacy, and Pharmacokinetics of Continuous Subcutaneous Lenalidomide in Multiple Myeloma (MM)

NCT ID: NCT06087653
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a new way to give lenalidomide (a continuous under-the-skin infusion called STAR-LLD) combined with dexamethasone and a proteasome inhibitor for people with multiple myeloma who need second-line or later treatment. This approach may help patients by delivering steady levels of the cancer drug while potentially reducing side effects compared to taking daily pills, and it could improve how well the treatment works against multiple myeloma.
Third Opinion AI Generated Synopsis

In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET

NCT ID: NCT05093335
Age Range: 18+
Sex: ALL
Phase: Early 1
This study is testing a new imaging agent called [68Ga]-Pentixafor with PET/CT scans in patients who have blood cancers like multiple myeloma, non-Hodgkin lymphoma, or certain rare blood disorders, as well as some solid tumors. This special imaging technique may help doctors better see and track cancer cells by targeting a specific protein (CXCR4) that is often found on cancer cells, potentially leading to more accurate diagnosis and treatment monitoring for multiple myeloma patients.
Third Opinion AI Generated Synopsis

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

NCT ID: NCT06582017
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing QXL138AM, a new experimental treatment given by intravenous infusion every two weeks, in patients with advanced solid tumors (including ovarian, pancreatic, lung, breast, and other cancers) and multiple myeloma who have not responded to standard treatments. This is the first study to test QXL138AM in humans, combining an anti-CD138 antibody with interferon, which may offer a new treatment approach for patients with limited remaining therapy options.
Third Opinion AI Generated Synopsis

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05259839
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new treatment called etentamig combined with existing cancer medicines (pomalidomide, lenalidomide, or daratumumab with dexamethasone) for adults with multiple myeloma that has come back or stopped responding to previous treatments. The research aims to find the safest dose of etentamig when used with these established treatments and may offer patients with hard-to-treat multiple myeloma access to a promising new therapy that targets cancer cells differently than current options.
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Frontline T-cell Engager vs Autologous Stem Cell Transplant (ASCT) and Measurable Residual Disease (MRD)-Guided Sequential Intensification thERapy in Multiple Myeloma

NCT ID: NCT06974786
Age Range: 19+
Sex: ALL
Phase: 2
This study compares two treatment approaches for patients with newly diagnosed multiple myeloma who have already received initial therapy: one using T-cell engager drugs (elranatamab and daratumumab) and another using stem cell transplant followed by lenalidomide and daratumumab. The study uses advanced testing to measure tiny amounts of remaining cancer cells in the bone marrow, which may help doctors choose the most effective treatment and potentially improve long-term outcomes for multiple myeloma patients.
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Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma

NCT ID: NCT05199311
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination treatment of carfilzomib, iberdomide, and dexamethasone for patients with newly diagnosed multiple myeloma who are eligible for stem cell transplant. This research is unique because it combines iberdomide, a newer immune-boosting drug, with established multiple myeloma treatments, potentially offering patients a more effective approach to prepare for transplant and improve long-term outcomes.
Third Opinion AI Generated Synopsis

Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation

NCT ID: NCT05706766
Age Range: 18+
Sex: ALL
Phase: NA
This study examines whether a virtual, home-based exercise program combining aerobic and strength training for 8 weeks before stem cell transplant can help multiple myeloma patients improve their physical fitness and overall health. This approach is unique because it allows patients to participate in supervised exercise training from home, potentially helping them build strength and endurance before their transplant procedure, which may lead to better outcomes during recovery.
Third Opinion AI Generated Synopsis

Elimination of Minimal Residual Disease After Transplant

NCT ID: NCT05690984
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of dexamethasone, isatuximab, and lenalidomide to eliminate remaining cancer cells (minimal residual disease) in multiple myeloma patients who still have detectable disease after stem cell transplant. The treatment aims to help patients achieve complete remission by targeting cancer cells that standard transplant therapy was unable to eliminate, potentially improving long-term outcomes for multiple myeloma patients.
Third Opinion AI Generated Synopsis

A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma

NCT ID: NCT07099391
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a treatment approach for people with newly diagnosed multiple myeloma that involves starting with Dara-RVd (daratumumab, lenalidomide, bortezomib, and dexamethasone) for 3 cycles, then switching to Tec-RVd (teclistamab, lenalidomide, bortezomib, and dexamethasone). The study is unique because it combines two different antibody therapies in sequence and focuses specifically on patients with standard-risk multiple myeloma who are candidates for stem cell transplant, potentially offering a new treatment strategy that could improve outcomes while maintaining safety.
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A Study of Melphalan With or Without Siltuximab in People With Multiple Myeloma Having an Autologous Stem Cell Transplant

NCT ID: NCT06679829
Age Range: 60+
Sex: ALL
Phase: 2
This study compares melphalan chemotherapy given with or without siltuximab (an immune system drug) in multiple myeloma patients who are receiving an autologous stem cell transplant. The research aims to determine if adding siltuximab to a personalized dosing approach for melphalan works as well as the standard treatment and may help reduce symptoms after transplant.
Third Opinion AI Generated Synopsis

A Study of DSP-5336 in Relapsed/Refractory AML/ ALL With or Without MLL Rearrangement or NPM1 Mutation

NCT ID: NCT04988555
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a drug called Enzomenib (DSP-5336) in adults with relapsed or refractory acute leukemia (AML or ALL), and in some locations, patients with multiple myeloma who have not responded to standard treatments. The study is unique because it tests Enzomenib both alone and in combination with other cancer drugs like venetoclax and gilteritinib, potentially offering new treatment options for patients whose cancer has returned or stopped responding to previous therapies.
Third Opinion AI Generated Synopsis

Phase I/II Trial of Cord Blood-Derived NK Cells Genetically Engineered With NY-ESO-1 TCR/IL-15 Cell Receptor for Relapsed/Refractory Multiple Myeloma

NCT ID: NCT06066359
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests specially modified immune cells called NK cells, taken from cord blood and engineered with NY-ESO-1 TCR/IL-15 receptors, in patients with multiple myeloma that has returned or stopped responding to previous treatments. The treatment combines these genetically modified NK cells with chemotherapy drugs to potentially offer a new approach for patients whose cancer has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

64Cu-LLP2A for Imaging Hematologic Malignancies

NCT ID: NCT06636175
Age Range: 18+
Sex: ALL
Phase: Early 1
This study is testing an imaging agent called 64Cu-LLP2A with PET/CT scans to better detect multiple myeloma and low-grade lymphoma in patients with these blood cancers. The study is unique because it uses a new formulation of this imaging agent that may provide clearer pictures of cancer cells, potentially helping doctors better track disease and detect cancer recurrence after bone marrow transplants.
Third Opinion AI Generated Synopsis

Pilot Study Using Changes in Serum BCMA to Determine Disease Progression in Multiple Myeloma

NCT ID: NCT06209606
Age Range: 18+
Sex: ALL
Phase: Early 1
This study is testing a combination treatment of ruxolitinib, steroids, and lenalidomide for patients with multiple myeloma whose disease has gotten worse after trying at least two previous treatments. What makes this study unique is that it uses changes in a blood marker called BCMA to detect disease progression, which may help doctors identify when the cancer is advancing earlier than traditional methods.
Third Opinion AI Generated Synopsis

Wearable Sensors and Molecular Omics to Detect and Mitigate Cell Therapy Adverse Events

NCT ID: NCT05123001
Age Range: 18+
Sex: ALL
Phase: NA
This study monitors patients receiving CAR-T cell therapy (a type of immunotherapy treatment) for blood cancers including multiple myeloma, lymphoma, and leukemia using wearable sensors and blood tests. The research aims to detect serious side effects like cytokine release syndrome and brain toxicity earlier and more precisely, which could lead to better management of these complications and improved safety for patients undergoing CAR-T therapy.
Third Opinion AI Generated Synopsis

Elranatamab in R/R Multiple Myeloma

NCT ID: NCT06138275
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing elranatamab, a targeted therapy drug, in patients with multiple myeloma that has returned or stopped responding to treatment after receiving idecabtagene vicleucel (a CAR-T cell therapy). The research aims to determine if elranatamab can reduce the risk of disease progression and provide an effective treatment option for patients whose cancer has relapsed following this advanced cellular therapy.
Third Opinion AI Generated Synopsis

Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma

NCT ID: NCT06048250
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing mezigdomide (CC-92480), a new cancer drug, in patients with multiple myeloma that has returned after treatment with Abecma CAR T-cell therapy. The unique approach of giving mezigdomide after CAR T-cell therapy may help the modified immune cells stay active longer in the body, potentially extending the time before the cancer comes back.
Third Opinion AI Generated Synopsis

Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma

NCT ID: NCT05145400
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing a combination of three cancer drugs (isatuximab, lenalidomide, and dexamethasone) at lower than usual doses for frail or much older patients with newly diagnosed Multiple Myeloma. The study aims to determine if using reduced doses can maintain treatment effectiveness while reducing harmful side effects commonly seen with standard-dose treatments in this vulnerable patient population.
Third Opinion AI Generated Synopsis

Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM

NCT ID: NCT04176718
Age Range: 18 - 80
Sex: ALL
Phase: 2
This study is testing a combination treatment using daratumumab, carfilzomib, pomalidomide, and dexamethasone for patients with multiple myeloma that has returned or stopped responding to previous treatments. This research is unique because it combines two newer cancer drugs (daratumumab and carfilzomib) with two standard treatments, potentially offering multiple myeloma patients a new option when their disease has become resistant to other therapies.
Third Opinion AI Generated Synopsis

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

NCT ID: NCT04991103
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing whether doctors can safely delay stem cell transplant in patients with newly diagnosed multiple myeloma by using advanced genetic testing to measure tiny amounts of remaining cancer cells after treatment with the drug combination DaraVRD. This personalized approach could help patients avoid the risks and side effects of immediate transplant while maintaining the same cancer control, potentially improving quality of life without compromising long-term outcomes.
Third Opinion AI Generated Synopsis

Molecular Imaging of Primary Amyloid Cardiomyopathy

NCT ID: NCT02641145
Age Range: 18 - 99
Sex: ALL
Phase: NA
This study is testing advanced imaging methods (including PET scans and MRI) to better visualize amyloid protein deposits in the hearts of people with primary amyloidosis, a rare disease where abnormal proteins build up in organs. This research aims to help doctors understand how these protein deposits damage heart function, which could lead to the development of new life-saving treatments for patients with this serious condition.
Third Opinion AI Generated Synopsis

A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

NCT ID: NCT04973605
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing sonrotoclax, a new cancer drug, either alone or in combination with other treatments like dexamethasone, carfilzomib, daratumumab, and pomalidomide for patients with multiple myeloma that has returned or stopped responding to previous treatments. The study specifically focuses on patients whose cancer cells have a genetic change called t(11;14) translocation, which may make this treatment more effective for this particular group of multiple myeloma patients.
Third Opinion AI Generated Synopsis

CAR T-cell Therapy in Patients With Renal Dysfunction

NCT ID: NCT05909059
Age Range: 18+
Sex: ALL
Phase: 2
This study examines CAR T-cell therapy, an advanced immune treatment, for patients with multiple myeloma, leukemia, or lymphoma who have moderate to severe kidney problems. The research is unique because it tests whether adjusting the doses of chemotherapy drugs given before CAR T-cell treatment can make this therapy safer and more feasible for patients with kidney dysfunction.
Third Opinion AI Generated Synopsis

PRO and Wearable Data Insights From Individuals With R/R Multiple Myeloma

NCT ID: NCT05956457
Age Range: 18+
Sex: ALL
Phase: NA
This study is testing a digital health coaching program that includes weekly phone calls, educational materials, and wearable fitness trackers for adults with relapsed or refractory multiple myeloma (cancer that has returned or stopped responding to treatment). The program aims to better understand patients' daily experiences and may help improve quality of life, symptom management, and confidence in managing their health condition.
Third Opinion AI Generated Synopsis

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

NCT ID: NCT07013474
Age Range: 18+
Sex: ALL
Phase: 3
This study examines whether ibuzatrelvir (alone or combined with remdesivir) works better than remdesivir alone to treat COVID-19 in adults with severely weakened immune systems due to conditions like multiple myeloma, organ transplants, or certain cancer treatments. This research is important because people with compromised immune systems often have more difficulty fighting off COVID-19 infections and may benefit from stronger antiviral treatment combinations.
Third Opinion AI Generated Synopsis

A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

NCT ID: NCT05640843
Age Range: 18+
Sex: ALL
Phase: NA

This clinical study is testing whether a plant-based diet or special supplements can help people with early stages of multiple myeloma by measuring changes in their gut bacteria. What makes this trial unique is that it's using pre-made plant-based meals delivered weekly and comparing them to omega-3 and curcumin supplements to see which approach works best for potentially preventing the disease from getting worse.

DISCOVERY: Evaluating a Decision Support Tool for Adults Seen in Hematology/Oncology Clinics

NCT ID: NCT06296368
Age Range: 60+
Sex: ALL
Phase: NA
This study is testing a digital decision support tool called PRIME for adults aged 60 and older who are newly diagnosed with blood cancers including multiple myeloma, lymphoma, or leukemia. The tool helps patients communicate their personal values and preferences to their doctors, which may lead to treatment decisions that better match what matters most to each patient.
Third Opinion AI Generated Synopsis

Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate Cancer

NCT ID: NCT04731844
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether curcumin and piperine supplements can help patients with early-stage prostate cancer on active surveillance or those being monitored for certain blood protein disorders that may develop into multiple myeloma. The research explores whether these natural compounds might slow disease progression in patients who are not yet receiving standard cancer treatments, potentially offering a safe way to delay the need for more intensive therapies.
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Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

NCT ID: NCT03937635
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing whether adding daratumumab (an immunotherapy drug) to the standard treatment of lenalidomide and dexamethasone works better for patients with high-risk smoldering multiple myeloma, a pre-cancerous blood condition that may develop into active cancer. The research aims to determine if this three-drug combination can delay or prevent the progression to active multiple myeloma better than the two-drug standard treatment alone.
Third Opinion AI Generated Synopsis

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06375044
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new experimental drug called SIM0500 in adults with multiple myeloma that has returned or stopped responding to previous treatments. The research uses a unique two-part approach that first finds the safest dose and then optimizes that dose, which may help doctors better understand how to use this potential new treatment for patients whose cancer has become difficult to treat.
Third Opinion AI Generated Synopsis

CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05722418
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing CB-011, a special type of immune cell therapy called CAR-T that uses genetically modified cells from healthy donors to target a protein called BCMA on cancer cells, for patients with multiple myeloma that has returned or stopped responding to treatment. This approach is unique because it uses donor cells that have been edited with CRISPR technology to potentially avoid rejection by the patient's immune system, which could make this treatment available to more patients without the need to use their own immune cells.
Third Opinion AI Generated Synopsis

A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study

NCT ID: NCT06271252
Age Range: 18 - 75
Sex: ALL
Phase: 1
This study is testing a new CAR-T cell therapy called OriCAR-017 in patients with relapsed or refractory multiple myeloma who have already tried at least three previous treatments and received BCMA-targeted therapies. What makes this treatment unique is that it targets a different protein called GPRC5D instead of BCMA, potentially offering new hope for multiple myeloma patients whose cancer has stopped responding to existing BCMA-based treatments.
Third Opinion AI Generated Synopsis

Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells

NCT ID: NCT03628612
Age Range: 1+
Sex: ALL
Phase: 2
This study follows patients with multiple myeloma and other blood cancers who previously received AUTO CAR T cell therapy, a treatment that uses genetically modified immune cells from the patient's own body to fight cancer. The research tracks patients for up to 15 years to monitor the long-term safety and effectiveness of this innovative immunotherapy, providing valuable information about how well these modified immune cells work over time.
Third Opinion AI Generated Synopsis

Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant

NCT ID: NCT05317416
Age Range: 18+
Sex: ALL
Phase: 3
This study compares elranatamab (given as an injection under the skin) to lenalidomide (taken as a daily pill) as maintenance treatment for patients with newly diagnosed multiple myeloma who have received a stem cell transplant. The study is unique because it tests whether elranatamab, a newer targeted therapy, can provide better long-term disease control than the current standard maintenance treatment, potentially offering multiple myeloma patients a more effective way to prevent their cancer from returning.
Third Opinion AI Generated Synopsis

Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma

NCT ID: NCT05972135
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether teclistamab or talquetamab cancer treatments can be safely given in an outpatient clinic setting for adults with multiple myeloma who have already tried at least two other treatments. The research focuses on making these effective treatments more convenient for patients by allowing them to receive care at home rather than staying in the hospital, while carefully monitoring their safety through close observation and regular check-ins.
Third Opinion AI Generated Synopsis

Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation

NCT ID: NCT04368559
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing whether Rezafungin, a new antifungal medication given through an IV, works better than standard antifungal drugs to prevent serious fungal infections in adults receiving blood and bone marrow transplants. This research is unique because it compares a newer, potentially more effective antifungal treatment to current standard care, which could lead to better protection against life-threatening fungal infections for transplant patients who are at high risk due to their weakened immune systems.
Third Opinion AI Generated Synopsis

Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06297226
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing Arlocabtagene Autoleucel (BMS-986393), a CAR T cell therapy that uses a patient's own immune cells to target GPRC5D protein, in adults with multiple myeloma that has returned or stopped responding to treatment. This treatment offers a new approach by engineering the patient's T cells to better recognize and attack multiple myeloma cells through a different target than previous therapies, potentially providing hope for patients who have tried multiple standard treatments.
Third Opinion AI Generated Synopsis

Integrated Actionable Aging Assessment for Cancer Patients Pilot

NCT ID: NCT05871008
Age Range: 65 - 111
Sex: ALL
Phase: NA
This study tests a new comprehensive assessment tool called IA3-CP that evaluates aging-related issues, mental health, social factors, and health behaviors in older cancer patients (age 65 and above) with various cancers including multiple myeloma. This integrated approach aims to help doctors provide more personalized, goal-focused care by identifying specific support needs and informing treatment decisions that consider the whole person, not just the cancer.
Third Opinion AI Generated Synopsis

A Study of Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Ciltacabtagene Autoleucel Versus Daratumumab, Bortezomib, Lenalidomide and Dexamethasone (DVRd) Followed by Autologous Stem Cell Transplant (ASCT) in Participants With Newly Diagnosed Multiple Myeloma

NCT ID: NCT05257083
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two treatment approaches for people newly diagnosed with multiple myeloma: a four-drug combination (daratumumab, bortezomib, lenalidomide, and dexamethasone) followed by either CAR-T cell therapy or stem cell transplant. This research may help determine whether CAR-T cell therapy, which uses genetically modified immune cells to fight cancer, could be as effective as or better than the standard stem cell transplant approach for treating multiple myeloma.
Third Opinion AI Generated Synopsis

Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma

NCT ID: NCT06876142
Age Range: 18 - 120
Sex: ALL
Phase: 1, 2
This study tests a combination of two oral medications, mirdametinib and sirolimus, in patients with relapsed or treatment-resistant multiple myeloma who have specific genetic changes (KRAS or NRAS mutations). This research is unique because it specifically targets multiple myeloma patients whose cancer has these particular genetic mutations and who have already tried multiple standard treatments, potentially offering a new treatment option for this difficult-to-treat patient population.
Third Opinion AI Generated Synopsis

Psilocybin Therapy in Advanced Cancer

NCT ID: NCT05398484
Age Range: 21 - 100
Sex: ALL
Phase: 2, 3
This study is testing psilocybin (a psychedelic compound) combined with brief psychotherapy to treat anxiety, depression, and existential distress in people with advanced cancer, including those with late-stage multiple myeloma or those receiving second-line therapy. This research is unique because it explores how a single dose of psilocybin, when paired with specialized counseling, may help multiple myeloma patients cope with the emotional challenges of their diagnosis and find greater meaning and hope during treatment.
Third Opinion AI Generated Synopsis

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

NCT ID: NCT05758493
Age Range: 18 - 90
Sex: ALL
Phase: 2
This study is testing a radioactive imaging agent called Iodine-124 Evuzumitide in patients with systemic amyloidosis, a condition where abnormal proteins build up in organs and tissues. The research uses advanced PET/MRI scanning to create detailed pictures showing where amyloid deposits are located in the body, which could help doctors better diagnose and monitor this disease.
Third Opinion AI Generated Synopsis

AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT06106945
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing AZD0305, a new cancer treatment that can be given alone or combined with other anticancer drugs, in patients with relapsed or refractory multiple myeloma who have already tried at least three different treatment approaches. The research aims to find the safest and most effective dose of AZD0305 while evaluating how well it works to control this hard-to-treat form of blood cancer.
Third Opinion AI Generated Synopsis

Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma

NCT ID: NCT04879043
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a new treatment called HDP-101 in patients with multiple myeloma that has returned or stopped responding to previous treatments. The treatment targets a specific protein called BCMA and may offer hope for patients who have already tried multiple standard therapies including immunomodulatory drugs, proteasome inhibitors, and anti-CD38 treatments.
Third Opinion AI Generated Synopsis

Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients

NCT ID: NCT05014646
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing leflunomide, a medication that reduces immune system activity, in African-American and European-American patients with high-risk smoldering multiple myeloma. The research focuses on whether this treatment can delay the progression of smoldering multiple myeloma to active disease, potentially giving patients more time before needing intensive cancer treatments.
Third Opinion AI Generated Synopsis

A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

NCT ID: NCT05201781
Age Range: 18+
Sex: ALL
Phase: 4
This study follows multiple myeloma patients who previously received ciltacabtagene autoleucel (cilta-cel), a personalized cell therapy treatment made from the patient's own immune cells. The research focuses on tracking long-term safety and any delayed side effects over time, which could help doctors better understand how to use this innovative treatment and what to expect for future multiple myeloma patients.
Third Opinion AI Generated Synopsis

Talquetamab in Combination With Iberdomide and Dexamethasone for Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06348108
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a combination of three medications - talquetamab, iberdomide, and dexamethasone - for patients with multiple myeloma that has returned after treatment or hasn't responded to previous therapies. This unique approach combines an FDA-approved drug that helps the immune system's T-cells target and destroy myeloma cells with an investigational drug and a steroid, potentially offering new hope for patients who have limited treatment options after their cancer has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

18F-Fluciclovine PET/CT in Multiple Myeloma

NCT ID: NCT06103838
Age Range: 18 - 120
Sex: ALL
Phase: 2
This study is testing a new imaging tracer called 18F-fluciclovine in PET/CT scans to detect multiple myeloma in adults with newly diagnosed or relapsed disease. The research aims to determine if this new tracer can find multiple myeloma more accurately than the current standard tracer (18F-FDG), which could help doctors detect returning cancer earlier and improve patient outcomes.
Third Opinion AI Generated Synopsis

Immunogenicity of Zoster Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients

NCT ID: NCT05554068
Age Range: N/A
Sex: ALL
Phase: 2
This study examines how well the Shingrix shingles vaccine works in patients who have received stem cell transplants from donors to treat blood cancers including multiple myeloma. This research is important because transplant patients have weakened immune systems that make them more vulnerable to shingles, and understanding vaccine effectiveness could help protect multiple myeloma patients from this painful infection.
Third Opinion AI Generated Synopsis

Minimal Residual Disease Guided Maintenance Therapy With Belantamab Mafodotin and Lenalidomide After Autologous Hematopoietic Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma

NCT ID: NCT05091372
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether a combination of belantamab mafodotin and lenalidomide can help maintain remission in newly diagnosed multiple myeloma patients who have recently received a stem cell transplant. The treatment is tailored based on minimal residual disease (MRD) testing, which looks for tiny amounts of remaining cancer cells to guide whether patients need more intensive maintenance therapy.
Third Opinion AI Generated Synopsis

Selinexor Treatment for Multiple Myeloma Patients Who Are Refractory to Lenalidomide-containing Therapy.

NCT ID: NCT04519476
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing selinexor, a new type of cancer drug, in combination with lenalidomide and methylprednisolone for patients with multiple myeloma whose cancer has stopped responding to lenalidomide-containing treatments. This research is unique because it targets a different pathway than standard treatments by blocking a protein that helps cancer cells survive, potentially offering a new treatment option for patients whose myeloma has become resistant to current therapies.
Third Opinion AI Generated Synopsis

A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma

NCT ID: NCT07105059
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing the combination of teclistamab and mezigdomide as a treatment for people with relapsed or refractory multiple myeloma who have already received at least two prior lines of therapy. This combination approach targets multiple myeloma through two different mechanisms, which may provide better disease control and offer a new treatment option for patients whose cancer has returned or stopped responding to previous therapies.
Third Opinion AI Generated Synopsis

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

NCT ID: NCT06615479
Age Range: 18+
Sex: ALL
Phase: 3

QUINTESSENTIAL-2 is a phase 3 clinical trial for patients with relapsed/refractory multiple myeloma who have had 1 to 3 prior treatments. The goal of this study is to test if an investigational CAR T-cell therapy called Arlocabtagene Autoleucel (arlo-cel) is safer and more effective than standard treatment options. There are more than 10 study sites currently open in the US.

Elotuzumab, Daratumumab, Iberdomide, and Dexamethasone for the Treatment of Relapsed Multiple Myeloma

NCT ID: NCT06785415
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination of four drugs (iberdomide, daratumumab, elotuzumab, and dexamethasone) for patients with multiple myeloma that has returned after previous treatments. This research is unique because it combines a new immune system drug (iberdomide) with three other proven cancer-fighting medications to potentially offer a more effective treatment option for patients whose cancer has come back despite receiving multiple prior therapies.
Third Opinion AI Generated Synopsis

Selinexor, Venetoclax, and Dexamethasone (XVenD) in t(11;14)-Positive Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05530421
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of three medicines (selinexor, venetoclax, and dexamethasone) in patients with multiple myeloma that has a specific genetic change called t(11;14) and has returned or stopped responding to previous treatments. This combination specifically targets the genetic weakness found in t(11;14) multiple myeloma, potentially offering a more effective treatment option for patients whose cancer has this particular genetic signature and has not responded to standard therapies including immunomodulatory drugs, proteasome inhibitors, and anti-CD38 antibodies.
Third Opinion AI Generated Synopsis

Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

NCT ID: NCT04508790
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of three drugs (leflunomide, pomalidomide, and dexamethasone) for patients with multiple myeloma that has returned or stopped responding to previous treatments. The research aims to determine if adding leflunomide to the standard combination of pomalidomide and dexamethasone can provide better treatment outcomes for patients who have already tried other therapies including proteasome inhibitors and immunomodulatory drugs.
Third Opinion AI Generated Synopsis

A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

NCT ID: NCT04133636
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing JNJ-68284528, a CAR-T cell therapy that targets a protein called BCMA, for patients with multiple myeloma at different stages of their disease. The treatment uses genetically modified immune cells to attack cancer cells and aims to achieve minimal residual disease negative status, which means reducing cancer to undetectable levels and may offer patients a more effective treatment option than current therapies.
Third Opinion AI Generated Synopsis

A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin Lymphoma

NCT ID: NCT05645107
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing whether XEMBIFY (a type of immunoglobulin therapy) combined with standard medical care can prevent serious bacterial infections in patients with Multiple Myeloma, chronic lymphocytic leukemia, or non-Hodgkin lymphoma who have low antibody levels and a history of severe or frequent infections. The treatment is unique because it is given under the skin every two weeks for one year, which may offer a more convenient way to boost the immune system and reduce infection rates compared to current prevention methods.
Third Opinion AI Generated Synopsis

Olanzapine 2.5 vs 5 mg in Quadruplet Nausea/Vomiting Prophylaxis Before High-Dose Melphalan

NCT ID: NCT06588413
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two different doses of olanzapine (2.5 mg versus 5 mg) combined with standard anti-nausea medications to prevent nausea and vomiting in multiple myeloma patients receiving high-dose melphalan chemotherapy before stem cell transplant. The research aims to find the lowest effective dose that controls nausea and vomiting while reducing the drowsiness side effect commonly seen with higher doses of olanzapine.
Third Opinion AI Generated Synopsis

IMMUNOPLANT for Newly Diagnosed Multiple Myeloma

NCT ID: NCT06376526
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing Linvoseltuximab, an immune system therapy, in patients with newly diagnosed multiple myeloma who have achieved a good response to initial treatment but still have detectable cancer cells. The goal is to determine if this treatment can eliminate remaining cancer cells and help patients stay in remission longer than current standard approaches.
Third Opinion AI Generated Synopsis

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

NCT ID: NCT03314974
Age Range: 60-
Sex: ALL
Phase: 2
This study is testing a stem cell transplant treatment using donor cells along with specific medications to prevent complications in patients with blood cancers including multiple myeloma, leukemia, and lymphoma. The treatment uses a gentler conditioning approach that may be safer for patients while still providing the cancer-fighting benefits of transplant, potentially offering hope for those who cannot tolerate more intensive treatments.
Third Opinion AI Generated Synopsis

A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)

NCT ID: NCT06083922
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination treatment called CyBorD (cyclophosphamide, bortezomib, and dexamethasone) plus daratumumab for people with monoclonal gammopathy of renal significance (MGRS), a condition where abnormal proteins damage the kidneys. The research aims to determine if this four-drug combination can safely and effectively treat kidney damage caused by MGRS, including cases related to multiple myeloma, potentially offering patients a new treatment option to protect their kidney function.
Third Opinion AI Generated Synopsis

A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma

NCT ID: NCT05651932
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing an oral medication called an MMSET inhibitor, either alone or combined with standard multiple myeloma drugs, in adults with relapsed or refractory multiple myeloma who have received at least three prior treatments. The MMSET inhibitor works through a new approach by blocking a specific protein that helps cancer cells grow, potentially offering another treatment option for patients whose cancer has stopped responding to other therapies.
Third Opinion AI Generated Synopsis

Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma

NCT ID: NCT05002816
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination of two approved cancer drugs, belantamab mafodotin and elotuzumab, for patients with multiple myeloma that has returned or stopped responding to at least three previous treatments. The research aims to determine if using these two treatments together is safer and more effective than using them alone, potentially offering a new treatment option for patients with advanced multiple myeloma.
Third Opinion AI Generated Synopsis

A Study of Combination of Selinexor, Pomalidomide, and Dexamethasone (SPd) Versus Elotuzumab, Pomalidomide, and Dexamethasone (EloPd) in Subject With Previously Treated Multiple Myeloma

NCT ID: NCT05028348
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two different combination treatments for people with multiple myeloma that has returned or stopped responding to previous therapies: one combining selinexor, pomalidomide, and dexamethasone versus another combining elotuzumab, pomalidomide, and dexamethasone. The research aims to determine which treatment combination works better and is safer for patients who have already tried multiple other therapies, potentially offering a new treatment option for those with limited remaining choices.
Third Opinion AI Generated Synopsis

S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration

NCT ID: NCT04071457
Age Range: 18 - 75
Sex: ALL
Phase: 3
This study compares lenalidomide alone versus lenalidomide combined with daratumumab/rHuPH20 as maintenance therapy for multiple myeloma patients who have completed stem cell transplant. The study uses a unique approach where treatment decisions after two years are guided by minimal residual disease (MRD) testing, which detects very small amounts of remaining cancer cells to help personalize how long patients continue treatment.
Third Opinion AI Generated Synopsis

A Diagnostic Study of CD38-Targeted ImmunoPET of Myeloma

NCT ID: NCT04814615
Age Range: 21+
Sex: ALL
Phase: 2
This study is testing a new imaging scan called immunoPET that uses a special tracer to detect multiple myeloma cancer cells in patients with this blood cancer. The scan may help doctors better see where myeloma is located in the body and determine how much cancer remains after treatment, which could improve treatment planning and monitoring.
Third Opinion AI Generated Synopsis

Personalized Autologous Transplant for Multiple Myeloma

NCT ID: NCT04483206
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a personalized dosing approach for melphalan chemotherapy in multiple myeloma patients receiving stem cell transplants. The unique approach analyzes each patient's blood levels after receiving part of their dose to determine the optimal personalized amount, which may lead to better treatment outcomes and fewer side effects compared to standard dosing methods.
Third Opinion AI Generated Synopsis

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

NCT ID: NCT06398457
Age Range: 18+
Sex: ALL
Phase: Early 1
This study tests whether Darzalex Faspro (daratumumab and hyaluronidase-fihj), a targeted antibody treatment, can help adult patients with blood cancers including multiple myeloma by lowering harmful antibodies that prevent successful stem cell transplants. This approach may allow patients who were previously unable to receive life-saving stem cell transplants due to high antibody levels to become eligible for this important treatment.
Third Opinion AI Generated Synopsis

APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT04942067
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing APG-2575 combined with existing cancer treatments in patients with multiple myeloma that has returned or stopped responding to previous treatments. The research explores whether adding APG-2575 to standard treatment combinations may improve outcomes for multiple myeloma patients by potentially making cancer cells more vulnerable to therapy.
Third Opinion AI Generated Synopsis

Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

NCT ID: NCT06052826
Age Range: 60+
Sex: ALL
Phase: 2
This study examines whether specialized health assessments and targeted interventions (including physical therapy, cognitive support, and nutrition counseling) can help patients aged 60 and older recover more quickly after receiving CAR-T cell therapy for multiple myeloma or B-cell non-Hodgkin lymphoma. The research aims to improve outcomes for older cancer patients by identifying their specific health needs before treatment and providing personalized care to reduce side effects and speed recovery from this advanced immunotherapy.
Third Opinion AI Generated Synopsis

Selinexor and Backbone Treatments of Multiple Myeloma Patients

NCT ID: NCT02343042
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing selinexor combined with various standard multiple myeloma treatments in patients with both newly diagnosed and relapsed/refractory multiple myeloma. The study evaluates 11 different treatment combinations across 12 treatment groups to determine the safest and most effective doses and treatment approaches for multiple myeloma patients who may benefit from this targeted therapy.
Third Opinion AI Generated Synopsis

Iberdomide and Daratumumab As Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma

NCT ID: NCT06107738
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether a combination of iberdomide and daratumumab medications can help maintain remission in multiple myeloma patients who still have detectable cancer cells after completing an autologous stem cell transplant. The research focuses specifically on patients with minimal residual disease and aims to determine if this dual-drug maintenance therapy can effectively eliminate remaining cancer cells while being safe and well-tolerated.
Third Opinion AI Generated Synopsis

Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

NCT ID: NCT06518551
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests a combination of three medications (Elotuzumab, Iberdomide, and Dexamethasone) in patients with multiple myeloma that has returned or stopped responding to treatment after receiving at least four previous therapies, including a recent CAR-T cell treatment called ide-cel. The research aims to determine if this drug combination can effectively control the cancer in patients who have already tried many treatments, potentially offering a new treatment option for those with heavily pre-treated multiple myeloma.
Third Opinion AI Generated Synopsis

A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

NCT ID: NCT05552222
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two new three-drug combinations (teclistamab with daratumumab and lenalidomide, or talquetamab with daratumumab and lenalidomide) against a standard three-drug treatment for people with newly diagnosed multiple myeloma who are not candidates for stem cell transplant. The study tests whether adding these newer targeted therapies to existing treatments can help patients live longer without their cancer getting worse compared to current standard care.
Third Opinion AI Generated Synopsis

Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease

NCT ID: NCT06627751
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination treatment of mezigdomide, carfilzomib, and dexamethasone for patients with multiple myeloma that has returned or stopped responding to treatment and has spread outside the bone marrow to other parts of the body. This combination is unique because it specifically targets patients with extramedullary disease (cancer spread beyond bone marrow), which is often harder to treat, and may offer better cancer control by combining three different types of anti-myeloma drugs that work through different mechanisms.
Third Opinion AI Generated Synopsis

Pilot Study Dara-CyBorD in Newly Diagnosed Multiple Myeloma Patients With Renal Failure

NCT ID: NCT06142396
Age Range: 18 - 80
Sex: ALL
Phase: Early 1
This study tests a combination treatment called Dara-CyBorD (daratumumab with cyclophosphamide, bortezomib, and dexamethasone) for newly diagnosed multiple myeloma patients who also have kidney failure. The research is unique because it specifically focuses on how well this treatment works to improve both cancer response and kidney function, while also examining whether treatment outcomes differ between African American and non-African American patients.
Third Opinion AI Generated Synopsis

iMMagine-3: A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

NCT ID: NCT06413498
Age Range: 18+
Sex: ALL
Phase: 3

iMMagine-3 is a phase 3, randomized clinical trial for people with relapsed or refractory multiple myeloma who have received 1 to 3 prior lines of therapy, including an anti-CD38 monoclonal antibody and immunomodulatory drug. The goal of the study is to evaluate if anitocabtagene autoleucel (anito-cel) is more effective than standard of care treatment (PVd, DPd, KDd, or Kd), as measured by progression free survival (the amount of time before the disease worsens).

Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma

NCT ID: NCT04640779
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a combination of two drugs, selinexor and choline salicylate, in patients with blood cancers including Multiple Myeloma, lymphoma, and certain rare blood cell cancers that have returned or did not respond to previous treatments. This research is unique because it combines a new type of cancer drug (selinexor) that blocks a protein needed for cancer cell growth with an anti-inflammatory medication (choline salicylate), potentially offering Multiple Myeloma patients a new treatment option when standard therapies have failed.
Third Opinion AI Generated Synopsis

Oral Adherence in Hematological Oncology Agents and Impact on Comorbid Therapy Adherence

NCT ID: NCT04663100
Age Range: 18+
Sex: ALL
Phase: NA
This study examines a care coordination model between cancer specialists and community pharmacists to help blood cancer patients (including those with multiple myeloma) who are starting oral cancer medications and also have multiple chronic health conditions manage all their medications better. The unique approach connects oncology and community pharmacists to provide comprehensive medication reviews and coordinated care, which may improve how well multiple myeloma patients take both their cancer treatments and other important medications.
Third Opinion AI Generated Synopsis

Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma

NCT ID: NCT03909412
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a combination of Carfilzomib with other drugs (Cyclophosphamide, Dexamethasone, and G-CSF) to help collect stem cells from multiple myeloma patients who need stem cell transplants. The research aims to find the best dose of Carfilzomib that can safely and effectively mobilize stem cells, which could improve transplant outcomes for patients who have previously been treated with Carfilzomib.
Third Opinion AI Generated Synopsis

Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma

NCT ID: NCT06169215
Age Range: N/A
Sex: ALL
Phase: 2
This study compares two different drug combinations for people newly diagnosed with high-risk multiple myeloma: one that includes a medication called selinexor along with three other drugs (daratumumab, velcade, and dexamethasone) versus the standard treatment combination (daratumumab, lenalidomide, velcade, and dexamethasone). This research is unique because it tests whether adding selinexor - a drug that works by blocking a specific protein to stop cancer cells from growing - as part of initial treatment may provide better outcomes for patients with high-risk multiple myeloma compared to current standard care.
Third Opinion AI Generated Synopsis

Remote Monitoring With Health-Coaching to Improve Quality of Life in Older Patients With Multiple Myeloma

NCT ID: NCT06145581
Age Range: 65+
Sex: ALL
Phase: NA
This study tests whether a home-based mindfulness and physical activity program combined with telephone health coaching can reduce fatigue and improve quality of life in older patients (65 and older) with multiple myeloma who are currently receiving maintenance treatment. This approach is unique because it combines gentle, home-based exercise with mindfulness techniques and personalized coaching support, which may help address the high symptom burden that multiple myeloma patients experience, particularly fatigue that significantly affects daily life.
Third Opinion AI Generated Synopsis

Study to Assess Safety and Tolerability of OPN-6602 in Subjects With Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT06433947
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new treatment called OPN-6602, either alone or combined with dexamethasone, for patients with multiple myeloma that has returned or stopped responding to at least three previous treatments. The study focuses on patients who have already tried standard treatments including immunomodulatory drugs, proteasome inhibitors, and anti-CD38 antibodies, offering a potential new option when other therapies are no longer effective.
Third Opinion AI Generated Synopsis

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

NCT ID: NCT03622788
Age Range: 12 - 75
Sex: ALL
Phase: 1, 2
This study is testing a treatment called cytokine-treated veto cells for patients with blood cancers (including multiple myeloma) who are receiving stem cell transplants from partially matched family donors. The special veto cells may help the transplanted stem cells grow successfully while reducing the risk of graft-versus-host disease, a serious complication where the donor cells attack the patient's healthy tissues.
Third Opinion AI Generated Synopsis

Iberdomide, Daratumumab, Bortezomib, and Dexamethasone for Treatment of Newly Diagnosed Multiple Myeloma, IDEAL Study

NCT ID: NCT05392946
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination of four medications - iberdomide, daratumumab, bortezomib, and dexamethasone - for patients who have been newly diagnosed with multiple myeloma. This research is unique because it combines a new immunotherapy drug (iberdomide) with three established treatments to potentially kill more cancer cells and help the body's immune system better fight the disease.
Third Opinion AI Generated Synopsis

A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments

NCT ID: NCT05714839
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing belantamab, a cancer drug, alone and in combination with another medication called belantamab mafodotin for patients with multiple myeloma who have received at least three previous treatments and whose cancer has continued to grow. The study is unique because it explores using belantamab by itself as a potential new treatment option, while also testing different combinations of these two related drugs to find the most effective and safe approach for patients with hard-to-treat multiple myeloma.
Third Opinion AI Generated Synopsis

Umbilical Cord Blood Transplantation From Unrelated Donors

NCT ID: NCT03016806
Age Range: 0 - 75
Sex: ALL
Phase: 1
This study is testing umbilical cord blood transplantation from unrelated donors as a treatment for patients with various blood cancers and disorders, including multiple myeloma, leukemia, lymphoma, and other conditions that may benefit from stem cell transplantation. This approach offers a potentially life-saving treatment option for multiple myeloma patients who cannot find a suitable bone marrow donor or are not eligible for their own stem cell transplant, providing access to stem cells that can help rebuild their blood and immune systems.
Third Opinion AI Generated Synopsis

A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma

NCT ID: NCT06577025
Age Range: 18 - 70
Sex: ALL
Phase: 2
This study is testing a combination of cancer treatments including Cilta-cel, Talquetamab, Daratumumab, and other medications for adults with newly diagnosed standard-risk Multiple Myeloma who have not received previous treatment. The study aims to find treatment sequences that could lead to a potential cure by achieving complete response with no detectable cancer cells for at least 2 years, which may offer Multiple Myeloma patients better long-term outcomes than current standard treatments.
Third Opinion AI Generated Synopsis

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

NCT ID: NCT03412877
Age Range: 18 - 72
Sex: ALL
Phase: 2
This study tests a personalized T-cell therapy that uses a patient's own immune cells, genetically modified to recognize specific mutations in their cancer, for people with advanced Multiple Myeloma and other cancers that have not responded to standard treatments. This approach is unique because it creates a customized treatment for each patient by targeting their tumor's specific genetic changes, potentially offering new hope for patients with hard-to-treat cancers.
Third Opinion AI Generated Synopsis

Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances

NCT ID: NCT05092451
Age Range: 12 - 80
Sex: ALL
Phase: 1, 2
This study is testing a combination treatment of specially modified natural killer (NK) immune cells from cord blood along with chemotherapy for patients with blood cancers that have returned or not responded to previous treatments, including multiple myeloma. The NK cells are engineered to better target cancer cells that have a specific protein called CD70, and they are enhanced with a growth factor (IL15) to potentially make them more effective at fighting cancer than standard treatments.
Third Opinion AI Generated Synopsis

Assessment of Multi-Level Interventions to Improve Adherence to Oral Medications in Cancer Patients

NCT ID: NCT03245411
Age Range: 18+
Sex: ALL
Phase: NA
This study is testing interventions to help cancer patients, including those with Multiple Myeloma, better take their oral cancer medications as prescribed. The research focuses on patients from diverse backgrounds who may face challenges with medication adherence, and aims to develop better support methods that could improve treatment outcomes for Multiple Myeloma patients taking oral therapies.
Third Opinion AI Generated Synopsis

A Study of Venetoclax in Combination With Isatuximab and Dexamethasone for Relapsed/Refractory Multiple Myeloma

NCT ID: NCT06115135
Age Range: N/A
Sex: ALL
Phase: 2
This study tests a combination of three drugs - venetoclax, isatuximab, and dexamethasone - in patients with multiple myeloma that has returned or stopped responding to previous treatments and carries a specific genetic change called t(11;14). The research focuses on patients with this particular genetic marker because the combination may be especially effective for their type of multiple myeloma, potentially offering a new treatment option when other therapies have failed.
Third Opinion AI Generated Synopsis

Allo HSCT Using RIC and PTCy for Hematological Diseases

NCT ID: NCT05805605
Age Range: 75-
Sex: ALL
Phase: 2
This study examines allogeneic stem cell transplant using a reduced-intensity conditioning regimen (chemotherapy with cyclophosphamide, fludarabine, and low-dose radiation) followed by post-transplant cyclophosphamide for patients with various blood cancers including Multiple Myeloma. This approach may benefit Multiple Myeloma patients by allowing the use of donors who are not perfect matches (including family members who are only partially matched) while potentially reducing transplant-related complications through the gentler conditioning regimen and innovative immune suppression strategy.
Third Opinion AI Generated Synopsis

Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma with Isatuximab

NCT ID: NCT05053607
Age Range: 18+
Sex: ALL
Phase: NA
This study examines the real-world experience of adults with relapsed or refractory multiple myeloma who are receiving isatuximab treatment as part of their standard care. What makes this study unique is its use of digital health coaching, wearable devices like Fitbit, and comprehensive patient surveys to track quality of life, treatment side effects, and daily activities over three months, providing detailed insights that could help improve care for future multiple myeloma patients.
Third Opinion AI Generated Synopsis

Defining the Role of Palliative carE for Patients With Hematologic Malignancies Undergoing Adoptive CEllular Therapy

NCT ID: NCT05646576
Age Range: 18+
Sex: ALL
Phase: NA
This study examines whether adding palliative care support to standard treatment can improve quality of life for patients with blood cancers (including multiple myeloma, lymphoma, and leukemia) who are receiving adoptive cellular therapy. The research is unique because it specifically focuses on how specialized supportive care during advanced cell therapy treatments may help patients better manage symptoms and improve their overall treatment experience.
Third Opinion AI Generated Synopsis

Low-Dose Radiotherapy in Treating Painful Bone Metastases in Patients With Multiple Myeloma

NCT ID: NCT03858205
Age Range: 18+
Sex: ALL
Phase: NA
This study tests low-dose radiation therapy to treat bone pain in multiple myeloma patients whose cancer has spread to their bones. The low-dose approach may offer patients more convenience, fewer side effects, and less interference with their chemotherapy treatment compared to standard radiation doses.
Third Opinion AI Generated Synopsis

Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma

NCT ID: NCT06073353
Age Range: 18+
Sex: ALL
Phase: NA
This study is testing a mobile phone app called THRIVE-M that provides psychological and social support for people living with multiple myeloma at different stages of their treatment. The app offers a unique digital approach to help patients improve their quality of life, reduce emotional distress, and manage fatigue compared to standard care alone.
Third Opinion AI Generated Synopsis

Selinexor, Carfilzomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT02199665
Age Range: 18+
Sex: ALL
Phase: 1
This clinical trial studies the combination of selinexor, carfilzomib, and dexamethasone as a treatment for patients with multiple myeloma that has returned after previous treatment or does not respond to standard therapies. This study is unique because it combines two targeted cancer drugs (selinexor and carfilzomib) with a steroid (dexamethasone) to potentially provide a more effective treatment option for patients whose multiple myeloma has become resistant to other therapies.
Third Opinion AI Generated Synopsis

EMPOWER 3: Improving Palliative Care Health Literacy and Utilization

NCT ID: NCT04733469
Age Range: 18+
Sex: ALL
Phase: NA
This study tests an educational video program designed to help cancer patients better understand and use palliative care services, which focus on improving comfort and quality of life during serious illness. The program is unique because it combines multimedia education with personalized materials to increase patients' knowledge about palliative care options, potentially leading to better symptom management and emotional well-being.
Third Opinion AI Generated Synopsis

Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies

NCT ID: NCT05981209
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a combination of three drugs - elotuzumab, CC-92480, and dexamethasone - for patients with multiple myeloma that has returned or stopped responding to treatment, specifically after they have already tried CD38- and BCMA-targeted therapies. This research is unique because it explores a new three-drug combination for patients whose cancer has become resistant to some of the newest available treatments, potentially offering hope for those who have run out of standard treatment options.
Third Opinion AI Generated Synopsis

Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL

NCT ID: NCT00881920
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new treatment called kappa-CD28 T lymphocytes for patients with multiple myeloma, chronic lymphocytic leukemia, or B-cell lymphoma that has returned or not responded to previous treatments. The treatment combines specially modified immune cells (T cells) with antibodies that target cancer cells, and includes a protein called CD28 that helps the T cells last longer in the body and work more effectively against cancer.
Third Opinion AI Generated Synopsis

A Study of Belantamab Mafodotin in Multiple Myeloma Participants With Normal and Impaired Hepatic Function

NCT ID: NCT04398680
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing belantamab mafodotin, a targeted therapy, in patients with relapsed or refractory multiple myeloma who have normal liver function compared to those with impaired liver function. The research uniquely examines how liver problems affect how the body processes this treatment, which could help doctors better determine safe and effective dosing for multiple myeloma patients with liver complications.
Third Opinion AI Generated Synopsis

Limited-duration Teclistamab

NCT ID: NCT05932680
Age Range: 18+
Sex: ALL
Phase: 2
This study examines stopping teclistamab treatment in multiple myeloma patients who have responded very well to 6-9 months of this targeted therapy, instead of continuing treatment indefinitely. The research aims to determine if patients can safely take breaks from treatment while maintaining their cancer response, potentially reducing infection risks and other side effects associated with continuous therapy.
Third Opinion AI Generated Synopsis

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

NCT ID: NCT05969860
Age Range: 18+
Sex: ALL
Phase: 2
This study compares giving cancer treatment at home versus in a clinic for patients with advanced cancers, including Multiple Myeloma, who are receiving specific IV medications like bortezomib, carfilzomib, or daratumumab. This research is unique because it evaluates whether home-based cancer treatment can reduce the physical, emotional, and financial burden on Multiple Myeloma patients and their families while maintaining the same quality of care as traditional clinic-based treatment.
Third Opinion AI Generated Synopsis

Elranatamab in Relapsed/Refractory Multiple Myeloma

NCT ID: NCT06711705
Age Range: 18+
Sex: ALL
Phase: 2
This study tests elranatamab, a new cancer treatment, in patients with multiple myeloma (a blood cancer) that has returned or stopped responding to previous treatments including CAR T-cell therapy, proteasome inhibitors, and immunomodulatory drugs. Elranatamab is unique because it works as a bispecific antibody that helps the immune system target and destroy myeloma cells, potentially offering a new treatment option for patients whose cancer has become difficult to treat with standard therapies.
Third Opinion AI Generated Synopsis

LINKER-MM4: A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

NCT ID: NCT05828511
Age Range: 18+
Sex: ALL
Phase: 1, 2

LINKER-MM4 is a clinical trial for people with newly diagnosed multiple myeloma. This study is looking at how safe Lynozyfic (linvoseltamab) is, how well patients can tolerate it, and whether it can be an effective early treatment option for newly diagnosed patients.

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

NCT ID: NCT01758042
Age Range: 18 - 70
Sex: ALL
Phase: NA
This study is testing a combined bone marrow and kidney transplant from a partially matched family member for patients who have both chronic kidney disease and blood disorders like multiple myeloma. This unique approach may reduce the risk of kidney rejection and decrease the need for long-term anti-rejection medications, since receiving bone marrow from the same donor helps the patient's immune system accept the transplanted kidney.
Third Opinion AI Generated Synopsis

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

NCT ID: NCT06904066
Age Range: 18 - 120
Sex: ALL
Phase: 1
This study is testing engineered T cells (a type of immune cell) that are modified to target specific cancer proteins in patients with blood cancers like multiple myeloma and leukemia. The treatment is personalized for each patient based on specific genetic mutations (TP53 or RAS) found in their cancer cells and their unique immune system markers.
Third Opinion AI Generated Synopsis

A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT05650632
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing ABBV-383, an experimental intravenous treatment, in adults with multiple myeloma that has returned or stopped responding to previous treatments. The research explores different dosing strategies and includes testing outpatient administration, which could offer patients more convenient treatment options if the therapy proves effective.
Third Opinion AI Generated Synopsis

Measurable Residual Disease-Guided Post-Transplant Elranatamab Maintenance

NCT ID: NCT06483100
Age Range: 18+
Sex: ALL
Phase: 2
This study tests elranatamab, a targeted cancer drug, as maintenance treatment for multiple myeloma patients after stem cell transplant, using specialized blood tests to guide when treatment is needed. This personalized approach uses advanced testing to detect tiny amounts of remaining cancer cells and may help doctors provide more precise treatment timing to improve long-term outcomes for patients.
Third Opinion AI Generated Synopsis

A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

NCT ID: NCT05652335
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing JNJ-79635322, an experimental treatment, in patients with multiple myeloma that has returned or stopped responding to treatment, as well as in patients with previously treated AL amyloidosis (a related blood disorder). The research aims to find the safest and most effective dose of this new medication and may offer hope for patients who have limited treatment options after their cancer has not responded to standard therapies.
Third Opinion AI Generated Synopsis

Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse

NCT ID: NCT06910124
Age Range: N/A
Sex: ALL
Phase: 2
This study is testing whether adding the drug linvoseltamab to standard lenalidomide maintenance therapy can help patients with newly diagnosed multiple myeloma achieve deeper treatment responses or regain complete remission after experiencing disease relapse. The combination aims to eliminate remaining cancer cells that current testing methods can detect, potentially extending the time patients remain in remission and improving long-term disease control compared to maintenance therapy alone.
Third Opinion AI Generated Synopsis

Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma

NCT ID: NCT04822337
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests a combination treatment of carfilzomib, lenalidomide, dexamethasone, and belantamab mafodotin for patients with multiple myeloma, including both newly diagnosed high-risk cases and patients whose cancer has returned or not responded to previous treatments. The study is unique because it combines a new antibody-drug therapy (belantamab mafodotin) with proven standard medications, potentially offering multiple myeloma patients a more effective treatment option that targets cancer cells through different mechanisms.
Third Opinion AI Generated Synopsis

Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

NCT ID: NCT05469893
Age Range: 18+
Sex: ALL
Phase: 2
This study compares the cancer drug Teclistamab to the combination of Lenalidomide and Dexamethasone for treating people with high-risk smoldering multiple myeloma, a condition where abnormal plasma cells are present but have not yet caused symptoms. This research is unique because it tests whether early treatment with these medications can prevent or delay the progression to active multiple myeloma, potentially helping patients avoid the serious complications that occur when the disease becomes symptomatic.
Third Opinion AI Generated Synopsis

A Study of CLN-619 (Anti-MICA/MICB Antibody) in Patients With Relapsed and Refractory Multiple Myeloma

NCT ID: NCT06381141
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing CLN-619, a new antibody treatment that targets specific proteins (MICA/MICB) on cancer cells, in patients with multiple myeloma that has returned or stopped responding to previous treatments. The treatment works by helping the immune system better recognize and attack myeloma cells through a novel approach that may offer hope for patients who have run out of other treatment options.
Third Opinion AI Generated Synopsis

Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia

NCT ID: NCT06976476
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing IgPro20, an antibody treatment, to prevent infections in multiple myeloma patients who have developed low antibody levels (hypogammaglobulinemia) after receiving bispecific antibody treatments. This research is unique because it specifically addresses a common side effect of newer multiple myeloma therapies, potentially offering patients a way to maintain their cancer treatment while reducing their risk of serious infections.
Third Opinion AI Generated Synopsis

Subcutaneous Talquetamab in Elderly Patients With Multiple Myeloma in Early Relapse

NCT ID: NCT06827860
Age Range: 70+
Sex: ALL
Phase: 2
This study is testing subcutaneous talquetamab, a bispecific antibody treatment, for elderly patients with multiple myeloma that has returned after at least two previous treatments. The study is unique because it uses a gentler injection method under the skin and can add a second drug called daratumumab if the first treatment doesn't work well enough, potentially offering an effective yet tolerable treatment option for older patients who may not be candidates for more aggressive therapies.
Third Opinion AI Generated Synopsis

A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma

NCT ID: NCT05675449
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing new combinations of medicines (elranatemab with carfilzomib and dexamethasone, or elranatemab with maplirpacept) for people with multiple myeloma that has returned or stopped responding to previous treatments. This research is unique because it explores how these specific drug combinations work together and aims to find the safest doses, potentially offering new treatment options for patients whose cancer has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

NCT ID: NCT04068597
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a new drug called CCS1477 (inobrodib) in patients with blood cancers including Multiple Myeloma, Non-Hodgkin Lymphoma, and Acute Myeloid Leukemia whose cancer has returned or stopped responding to previous treatments. The research aims to determine the safest dose of this experimental medication and evaluate how well it works, potentially offering a new treatment option for patients who have tried standard therapies without success.
Third Opinion AI Generated Synopsis

Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ...

NCT ID: NCT05470491
Age Range: 12 - 120
Sex: ALL
Phase: 1, 2
This study is testing a new combination of medications (cyclophosphamide, maraviroc, and bortezomib) to prevent graft-versus-host disease after bone marrow transplant in people with HIV and blood cancers like multiple myeloma. The research aims to determine if this drug combination can better protect patients from serious transplant complications while maintaining cancer control and survival rates.
Third Opinion AI Generated Synopsis

Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

NCT ID: NCT06022939
Age Range: 18+
Sex: ALL
Phase: 3
This study compares daratumumab plus chemotherapy (Dara-VCD) alone versus the same treatment followed by stem cell transplant in people with newly diagnosed AL amyloidosis, a disease where abnormal proteins build up in organs and tissues. The research aims to determine whether adding stem cell transplant after chemotherapy provides better outcomes than chemotherapy alone, potentially offering patients a more effective treatment approach for this serious condition.
Third Opinion AI Generated Synopsis

A Study of Whether Ide-cel (bb2121) Can Be Made From People With Multiple Myeloma Who Have Had a Hematopoietic Cell Transplant

NCT ID: NCT05393804
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing ide-cel (bb2121), a CAR-T cell therapy, in people with multiple myeloma who have already received a stem cell transplant but whose cancer has returned or stopped responding to treatment. The research focuses on understanding how the quality of a patient's T cells affects how well this personalized cell therapy works to prevent cancer from coming back.
Third Opinion AI Generated Synopsis

CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myeloma

NCT ID: NCT03710421
Age Range: 18+
Sex: ALL
Phase: 1
This study tests CS1-CAR T therapy, a treatment that uses genetically modified immune cells to target CS1 proteins on cancer cells, for patients with multiple myeloma that has returned or stopped responding to treatment. This approach offers a new way to harness the patient's own immune system to specifically attack multiple myeloma cells that carry the CS1 protein, potentially providing an effective treatment option when standard therapies have failed.
Third Opinion AI Generated Synopsis

Imaging Study of [89Zr]DFO-YS5 for Detecting CD46 Positive Malignancy in Multiple Myeloma

NCT ID: NCT05892393
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new imaging scan called [89Zr]DFO-YS5 PET that uses a small amount of radioactive material to better detect multiple myeloma cancer cells in patients who already have this blood cancer. This new scan specifically targets a protein called CD46 that is found on certain multiple myeloma cells, which may help doctors see the cancer more clearly than current imaging methods and improve treatment planning for patients.
Third Opinion AI Generated Synopsis

The Ambient Light Multiple Myeloma Study

NCT ID: NCT05737732
Age Range: 21+
Sex: ALL
Phase: NA
This study examines whether specialized lighting treatments can help multiple myeloma patients who are receiving their first stem cell transplant by improving their natural sleep-wake cycles. The research is unique because it explores how light therapy might reduce inflammation, lower fever risk, and decrease symptoms during transplant recovery by helping patients maintain healthier daily rhythms.
Third Opinion AI Generated Synopsis

Selinexor for the Treatment of Intermediate and High-Risk Smoldering Multiple Myeloma

NCT ID: NCT05597345
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing the drug Selinexor for treating patients with smoldering multiple myeloma (an early stage of blood cancer) who have intermediate or high risk of their disease getting worse. This research is unique because it uses a low-dose version of an already approved cancer drug to potentially delay or prevent smoldering multiple myeloma from progressing to active multiple myeloma, offering hope for early intervention in patients most likely to develop symptoms.
Third Opinion AI Generated Synopsis

AI Echocardiographic Screening of Cardiac Amyloidosis

NCT ID: NCT06664866
Age Range: 22+
Sex: ALL
Phase: NA
This study is testing an artificial intelligence (AI) tool called EchoNet-LVH that analyzes heart ultrasounds (echocardiograms) to screen for cardiac amyloidosis, a rare heart disease where abnormal proteins build up in the heart muscle. The AI system is designed to identify patients who may have this often-missed condition by detecting suspicious patterns in routine heart scans that doctors might overlook, potentially leading to earlier diagnosis and treatment for Multiple Myeloma patients who are at higher risk for developing cardiac amyloidosis.
Third Opinion AI Generated Synopsis

Belantamab Mafadotin Maintenance Therapy After Salvage Autologous Hematopoietic Cell Transplantation in Patients With Relapse Refractory Multiple Myeloma

NCT ID: NCT05065047
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing whether belantamab mafodotin (Blenrep) can help prevent multiple myeloma from returning in patients who have had a stem cell transplant using their own cells after their cancer came back or stopped responding to treatment. This research is unique because it focuses on using this targeted therapy as maintenance treatment specifically after salvage transplant, which may help keep patients in remission longer and improve their long-term outcomes.
Third Opinion AI Generated Synopsis

Wellness App for Sleep Disturbance in Hematological Cancer Patients

NCT ID: NCT05294991
Age Range: 18+
Sex: ALL
Phase: NA

The goal of this 20-week study is to see if a digital wellness app can help improve sleep, immune function, and other behavior outcomes for people diagnosed with blood cancers like multiple myeloma. Participants will use one of two digital wellness apps 10 minutes per day over 8-weeks to determine how well the app works. This study is completely remote (no in-person visits) and patients from across the USA are invited. Enrolled participants will be compensated.

IDP-023 as a Single Agent and in Combination With Antibody Therapies in Patients With Advanced Hematologic Cancers

NCT ID: NCT06119685
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a new drug called IDP-023, used alone or combined with antibody treatments, in patients with advanced blood cancers including multiple myeloma that has returned or stopped responding to at least three previous treatments. This research is unique because it's the first time IDP-023 has been tested in humans, and it may offer multiple myeloma patients a new treatment option when other therapies have failed.
Third Opinion AI Generated Synopsis

A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2)

NCT ID: NCT05552976
Age Range: 18+
Sex: ALL
Phase: 3
This study compares a new three-drug combination treatment (mezigdomide, carfilzomib, and dexamethasone) against a standard two-drug combination (carfilzomib and dexamethasone) for patients with multiple myeloma that has returned or stopped responding to previous treatments. The addition of mezigdomide to the existing treatment may help control the cancer more effectively and provide better outcomes for patients whose disease has progressed despite prior therapies.
Third Opinion AI Generated Synopsis

SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06622005
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a new drug called SX-682 combined with three standard multiple myeloma treatments (carfilzomib, daratumumab-hyaluronidase, and dexamethasone) in patients whose cancer has returned after treatment or has not responded to previous therapies. SX-682 works by blocking certain sites on cells that normally prevent the immune system from attacking cancer cells, potentially allowing the body's natural defenses to better fight multiple myeloma when combined with proven treatments.
Third Opinion AI Generated Synopsis

Mosaic Trial for Stem Cell Transplant Recipients

NCT ID: NCT06960993
Age Range: 18+
Sex: ALL
Phase: NA
This study tests whether an interactive website called Mosaic helps blood cancer patients, including those with multiple myeloma, better manage their care during stem cell transplant compared to using a standard educational website. The Mosaic website may help patients feel more prepared for transplant and experience less distress, physical symptoms, and better quality of life throughout their treatment and recovery.
Third Opinion AI Generated Synopsis

The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft-versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant

NCT ID: NCT03805789
Age Range: 12+
Sex: ALL
Phase: 2, 3
This study is testing Alpha-1 Antitrypsin (AAT) medication to prevent graft-versus-host disease in patients with blood cancers, including multiple myeloma, who are receiving stem cell transplants from donors. This research offers a new approach to preventing a serious transplant complication that could make stem cell transplantation safer and more successful for multiple myeloma patients.
Third Opinion AI Generated Synopsis

Lymphodepleting Total Body Irradiation (TBI) Plus Cyclophosphamide Prior to Ciltacabtagene Autoleucel (Carvykti; Cilta-cel) for Multiple Myeloma (MM) Patients With Impaired Renal Function

NCT ID: NCT06623630
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new preparation method using low-dose radiation and chemotherapy before giving cilta-cel (a CAR T-cell therapy) to multiple myeloma patients who have kidney problems. This research is important because patients with kidney damage have been excluded from previous CAR T-cell studies, and this approach may provide a safer way to prepare their immune system for this potentially life-saving treatment.
Third Opinion AI Generated Synopsis

A Vaccine (VSV-hIFNβ-NIS) with or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

NCT ID: NCT03017820
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a modified virus vaccine (VSV-hIFNβ2-NIS) combined with different immune-boosting drugs for patients with multiple myeloma, acute myeloid leukemia, or lymphoma that has returned or doesn't respond to treatment. The vaccine uses a modified virus that specifically targets cancer cells while protecting healthy cells, and researchers will test it with various combinations of immunotherapy drugs to find the safest and most effective treatment approach.
Third Opinion AI Generated Synopsis

Safety and Efficacy of CS1 CAR-T (WS-CART-CS1) in Subjects With Multiple Myeloma

NCT ID: NCT06185751
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new CAR-T cell therapy called WS-CART-CS1 for patients with multiple myeloma that has returned or stopped responding to at least three previous treatments, including specific types of medications like proteasome inhibitors and anti-BCMA therapies. This treatment targets a different protein called CS1 on cancer cells, which may provide a new treatment option for patients whose cancer has become resistant to current CAR-T therapies that target BCMA.
Third Opinion AI Generated Synopsis

Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases

NCT ID: NCT06745024
Age Range: 18+
Sex: ALL
Phase: 3
This study compares radiation therapy combined with standard care to standard care alone for cancer patients who have high-risk bone metastases (cancer that has spread to bones) that are not currently causing symptoms. This research may help determine if preventive radiation therapy can better protect patients from serious bone complications like fractures or spinal cord compression before symptoms develop.
Third Opinion AI Generated Synopsis

A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments

NCT ID: NCT05020236
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing elranatamab, a new targeted therapy, both alone and combined with daratumumab, for patients with multiple myeloma who have already received other treatments including lenalidomide. The study is unique because it compares elranatamab as a single treatment and in combination against standard therapy, while also testing enhanced infection prevention measures to help keep patients safer during treatment.
Third Opinion AI Generated Synopsis

External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease

NCT ID: NCT06572605
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination of targeted radiation therapy and talquetamab (an antibody medication) for multiple myeloma patients whose cancer has spread to soft tissues and organs outside the bone marrow. The unique approach combines radiation directed at specific cancer sites with an antibody that helps the immune system fight cancer cells, potentially offering a new treatment option for this challenging form of multiple myeloma that has been difficult to treat with standard therapies.
Third Opinion AI Generated Synopsis

Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05896228
Age Range: 18 - 75
Sex: ALL
Phase: 2
This study tests a combination of four cancer drugs (iberdomide, daratumumab, carfilzomib, and dexamethasone) in patients with multiple myeloma that has returned or stopped responding to previous treatments. The study is unique because it combines these specific drugs together and measures whether the treatment can eliminate all detectable cancer cells in the body, which may help patients achieve longer-lasting remissions than current standard treatments.
Third Opinion AI Generated Synopsis

Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment

NCT ID: NCT05561387
Age Range: N/A
Sex: ALL
Phase: 3
This study compares three different combinations of cancer drugs (including bortezomib, lenalidomide, dexamethasone, and daratumumab) to treat newly diagnosed multiple myeloma in patients who cannot receive a stem cell transplant due to age or health conditions. The research aims to determine which drug combination works best to shrink tumors and control the disease in patients who are considered frail or have intermediate fitness levels.
Third Opinion AI Generated Synopsis

A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion Alone or in Combination With Oral, IV, Subcutaneous Daratumumab; Lenalidomide; Dexamethasone; Carfilzomib

NCT ID: NCT06892522
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests etentamig, an experimental drug, either alone or combined with standard multiple myeloma treatments in adult patients with newly diagnosed or relapsed/refractory multiple myeloma. The research explores different drug combinations to find the safest and most effective doses, potentially offering new treatment options for multiple myeloma patients whose cancer has returned or not responded to previous therapies.
Third Opinion AI Generated Synopsis

Sequential Therapy in Multiple Myeloma Guided by MRD Assessments

NCT ID: NCT05231629
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing a personalized treatment approach for patients with newly diagnosed Multiple Myeloma, where treatment decisions are guided by measuring minimal residual disease (MRD) - the amount of cancer cells remaining after treatment. The study aims to determine if patients who achieve very low cancer cell levels can maintain their response with additional drug therapy instead of stem cell transplant, potentially offering an effective alternative treatment path for Multiple Myeloma patients.
Third Opinion AI Generated Synopsis

Understanding the Mechanisms of Clonal and Non-clonal Cytopenia Following CAR-T Therapy for Multiple Myeloma or CD19+ Lymphoproliferative Disorder (LPD)

NCT ID: NCT06630104
Age Range: 18+
Sex: ALL
Phase: NA
This study examines how genetic changes affect low blood cell counts (cytopenia) in patients with multiple myeloma or certain blood cancers who receive CAR-T cell therapy, an advanced treatment that uses modified immune cells to fight cancer. By analyzing genetic mutations in blood and tissue samples, researchers aim to identify which patients are more likely to develop prolonged low blood cell counts after treatment, potentially helping doctors better predict and manage this common side effect.
Third Opinion AI Generated Synopsis

A Study of GC012F (AZD0120), a CAR T Therapy Targeting CD19 and BCMA in Subjects With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05850234
Age Range: 18+
Sex: ALL
Phase: 1, 2

This study is testing GC012F (AZD0120), a special type of immune cell therapy called CAR T therapy that targets two proteins (CD19 and BCMA) at the same time, in adults with multiple myeloma that has returned or stopped responding to treatment. This dual-target approach is unique because it attacks cancer cells through two different pathways simultaneously, which may help prevent the cancer from developing resistance and could provide better, longer-lasting results for patients whose multiple myeloma has not responded to at least three previous treatments.

Third Opinion AI Generated Synopsis

A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma (Excaliber)

NCT ID: NCT05827016
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two maintenance treatments, iberdomide and lenalidomide, for patients with newly diagnosed multiple myeloma who have received a stem cell transplant using their own cells. This research is unique because it directly tests whether the newer drug iberdomide can provide better long-term disease control than the current standard maintenance therapy, potentially helping patients stay in remission longer.
Third Opinion AI Generated Synopsis

Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple Myeloma

NCT ID: NCT05312255
Age Range: 18+
Sex: ALL
Phase: NA
This study examines non-drug treatments including exercise, nutrition changes, and a blood pressure medication called propranolol for patients with multiple myeloma and related blood cancers. The research aims to determine if these approaches can improve immune system function and quality of life by working alongside standard cancer treatments rather than replacing them.
Third Opinion AI Generated Synopsis

Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06203912
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a combination of specially modified immune cells from donors (called TGFβi NK cells) along with isatuximab, a targeted antibody therapy, in patients with multiple myeloma that has returned or stopped responding to previous treatments. This approach is unique because it uses laboratory-enhanced natural killer cells that are better at fighting cancer cells, combined with standard treatments, which may offer a new treatment option for patients whose multiple myeloma has not responded to at least three previous therapies including specific targeted drugs.
Third Opinion AI Generated Synopsis

Teclistamab or Talquetamab in Combination With Daratumumab for High-Risk Smoldering Myeloma (REVIVE Study)

NCT ID: NCT06100237
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing two different drug combinations (Teclistamab with Daratumumab or Talquetamab with Daratumumab) for patients with high-risk smoldering multiple myeloma, a precancerous condition that can develop into active multiple myeloma cancer. This research is unique because it aims to delay or prevent the progression from smoldering myeloma to active multiple myeloma, potentially helping patients avoid the more serious complications and symptoms that occur when the disease becomes active.
Third Opinion AI Generated Synopsis

Improving Cognitive Function in Older Adults Undergoing Stem Cell Transplant

NCT ID: NCT04898790
Age Range: 19+
Sex: ALL
Phase: NA
This study is testing a physical activity program called CHAMPS-II for older adults (55 and older) with blood cancers like multiple myeloma who are undergoing stem cell transplant. The research aims to understand how exercise might help protect thinking and memory skills during cancer treatment, which could lead to better quality of life and faster recovery for multiple myeloma patients.
Third Opinion AI Generated Synopsis

Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

NCT ID: NCT06482515
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing whether eating all food within a 10-hour daily window (called time-restricted eating) can reduce severe fatigue in people who have been treated for blood cancers like leukemia, lymphoma, or multiple myeloma. This approach is unique because it focuses on when patients eat rather than what they eat, and may help reset the body's internal clock that can be disrupted by cancer treatment, potentially offering a new way to manage the exhausting fatigue that often persists long after treatment ends.
Third Opinion AI Generated Synopsis

Dasatinib and Quercetin With CAR-T Therapy for the Treatment of Patients With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06940297
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing a combination treatment of dasatinib (a cancer-fighting drug), quercetin (a natural plant compound), and CAR-T cell therapy for patients with multiple myeloma that has returned or stopped responding to previous treatments. This approach is unique because it combines traditional chemotherapy with an advanced immune therapy that uses the patient's own modified immune cells to attack cancer, potentially offering a more effective treatment option for patients who have already tried multiple therapies.
Third Opinion AI Generated Synopsis

A Phase 1 With Extension Cohort, Single Arm, Single Center, Open Label Trial of Belantamab Mafodotin for the Treatment of High-Risk Smoldering Multiple Myeloma

NCT ID: NCT05055063
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a drug called belantamab mafodotin in patients with high-risk smoldering multiple myeloma, a condition where abnormal blood cells are present but have not yet caused symptoms. The treatment targets high-risk patients who have specific markers that suggest their disease may progress to active multiple myeloma, offering a potential way to prevent or delay the cancer from becoming more serious.
Third Opinion AI Generated Synopsis

Post-Autologous Transplant Maintenance With Isatuximab and Lenalidomide in Minimal Residual Disease Positive Multiple Myeloma

NCT ID: NCT05344833
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing a combination of isatuximab and lenalidomide as maintenance therapy for multiple myeloma patients who still have detectable cancer cells after receiving an autologous stem cell transplant. This research is unique because it specifically targets patients with minimal residual disease (MRD-positive status), potentially helping to eliminate remaining cancer cells and extend the time before the disease returns.
Third Opinion AI Generated Synopsis

Bortezomib, Isatuximab, Cyclophosphamide and Dexamethasone Induction in Transplant-Eligible Multiple Myeloma Patients With Renal Insufficiency

NCT ID: NCT04240054
Age Range: 18+
Sex: ALL
Phase: 2
This clinical trial is studying a combination of four cancer medications (Bortezomib, Isatuximab, Cyclophosphamide, and Dexamethasone) for newly diagnosed Multiple Myeloma patients who have kidney problems and are eligible for stem cell transplant. The study specifically focuses on patients with kidney insufficiency, which is an important group that needs specialized treatment approaches to help improve their outcomes before transplant.
Third Opinion AI Generated Synopsis

A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients

NCT ID: NCT03110822
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a combination treatment of ruxolitinib, steroids, and lenalidomide for patients with multiple myeloma whose cancer has returned or stopped responding to previous treatments. This research is unique because it combines ruxolitinib (a JAK inhibitor) with proven multiple myeloma drugs, potentially offering a new treatment option for patients who have already tried at least two other therapies including specific types of cancer medications.
Third Opinion AI Generated Synopsis

Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis

NCT ID: NCT05184088
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing a new imaging scan called [18F]florbetaben PET to help diagnose cardiac amyloidosis, a condition where abnormal proteins build up in the heart muscle, in patients who are suspected of having this disease. This imaging technique could provide doctors with a better, less invasive way to detect heart involvement in amyloidosis compared to current methods like heart biopsies.
Third Opinion AI Generated Synopsis

Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

NCT ID: NCT05862012
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new experimental treatment called ISB 2001 in patients with relapsed or refractory multiple myeloma, which means their cancer has returned or stopped responding to previous treatments. This is the first time ISB 2001 has been tested in humans, offering patients with hard-to-treat multiple myeloma access to a potentially new treatment option when standard therapies have not worked.
Third Opinion AI Generated Synopsis

High Dose Ascorbic Acid (HDAA) in Patients With Plasma Cell Disorders

NCT ID: NCT06313502
Age Range: 18 - 100
Sex: ALL
Phase: 1
This study is testing high-dose ascorbic acid (vitamin C) combined with a reduced dose of the chemotherapy drug melphalan, followed by stem cell transplant, in patients with multiple myeloma that has returned or stopped responding to treatment. The approach may provide similar cancer-fighting benefits while potentially reducing side effects by using only half the standard dose of melphalan when combined with high-dose vitamin C.
Third Opinion AI Generated Synopsis

Optimizing PTCy Dose and Timing

NCT ID: NCT03983850
Age Range: 12 - 120
Sex: ALL
Phase: 1, 2
This study is testing whether lower doses of the chemotherapy drug cyclophosphamide (PTCy) and shorter treatment with another immune-suppressing medication can help patients with blood cancers like multiple myeloma have safer stem cell transplants from family donors. The research aims to reduce transplant complications and side effects while maintaining the treatment's effectiveness, potentially offering patients a gentler approach to this life-saving therapy.
Third Opinion AI Generated Synopsis

Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies

NCT ID: NCT05887167
Age Range: 18 - 85
Sex: ALL
Phase: 1
This study tests whether combining special stem cells from a patient's own body with CAR T-cell therapy is safe and effective for people with blood cancers like multiple myeloma that have returned or stopped responding to treatment. This approach may help patients recover faster from CAR T-cell therapy and potentially improve long-term cancer control by using their own healthy stem cells alongside the engineered immune cells.
Third Opinion AI Generated Synopsis

A Study to Assess Adverse Events and Change in Disease Activity of Oral ABBV-453 Alone or in Combination With Subcutaneous and/or Oral Antimyeloma Agents in Adult Participants With Multiple Myeloma (MM)

NCT ID: NCT06953960
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing an investigational oral medication called ABBV-453, used alone or combined with standard multiple myeloma treatments, in adults whose multiple myeloma has returned or stopped responding to previous therapies. The study is unique because it focuses specifically on patients whose cancer has a certain genetic marker (t(11;14) or high BCL2) that may make them more likely to respond to this new targeted treatment approach.
Third Opinion AI Generated Synopsis

Phase 1/2 Study of REGN5458 in Adult Patients With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT03761108
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing REGN5458 (linvoseltamab), a new treatment for adults with multiple myeloma that has returned or stopped responding to previous therapies. This treatment is unique because it targets a specific protein called BCMA found on myeloma cells, potentially offering a new option for patients whose cancer has not responded to standard treatments including proteasome inhibitors, immunomodulatory drugs, and anti-CD38 antibodies.
Third Opinion AI Generated Synopsis

CAR- PRISM (PRecision Intervention Smoldering Myeloma)

NCT ID: NCT05767359
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing cilta-cel, a treatment that uses genetically modified immune cells (CAR-T therapy), combined with chemotherapy drugs for patients with high-risk smoldering multiple myeloma. This approach is unique because it aims to treat patients before their cancer becomes active, potentially preventing progression to full multiple myeloma and offering a chance for long-term disease control.
Third Opinion AI Generated Synopsis

Phase I/II Open Label Study of Belumosudil Mesylate Alone, and in Combination With Dexamethasone, in Patients With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT06105554
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing belumosudil mesylate, either alone or combined with dexamethasone, in patients with multiple myeloma that has returned or stopped responding to previous treatments. This research is unique because it focuses on patients whose cancer has become resistant to three major classes of myeloma drugs, potentially offering a new treatment option when standard therapies are no longer effective.
Third Opinion AI Generated Synopsis

Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid

NCT ID: NCT06910670
Age Range: 18+
Sex: ALL
Phase: NA
This study is testing a web-based decision aid tool to help patients with multiple myeloma, cholangiocarcinoma, and colorectal cancer make informed choices about receiving genetic test results. The research compares this interactive online tool to standard materials to see which approach better helps patients understand and decide what types of genetic information they want to learn from their cancer testing.
Third Opinion AI Generated Synopsis

Impact of Budesonide on Incidence of ≥ Gr2 Diarrhea in Multiple Myeloma (MM) Patients Undergoing Autologous Stem Cell Transplant

NCT ID: NCT05405387
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether budesonide, a medication that reduces inflammation in the digestive system, can prevent severe diarrhea in multiple myeloma patients receiving an autologous stem cell transplant. This research is unique because it specifically focuses on reducing a common and serious side effect of stem cell transplant treatment, which could improve patients' quality of life and recovery experience during this important cancer therapy.
Third Opinion AI Generated Synopsis

Isatuximab During Stem Cell Collection and Transplant in Patients With Multiple Myeloma and Lymphoma

NCT ID: NCT05346809
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing whether isatuximab, an antibody drug, can help strengthen the immune system's ability to fight cancer in patients with multiple myeloma and lymphoma who are receiving stem cell transplants. What makes this approach unique is that isatuximab is given during the stem cell collection and transplant process to potentially reset and enhance the immune system so it can better recognize and attack cancer cells after recovery from the transplant.
Third Opinion AI Generated Synopsis

Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients

NCT ID: NCT05823571
Age Range: 60+
Sex: ALL
Phase: 1

This study is testing whether itacitinib, a drug that reduces inflammation and immune system activity, can be safely given to patients 60 years and older with blood cancers including multiple myeloma who are receiving a "mini" stem cell transplant from a related donor. The research aims to prevent serious side effects like cytokine release syndrome and potentially reduce the need for long-term immune suppression medications after transplant, which could improve recovery and quality of life for older patients.

Third Opinion AI Generated Synopsis

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

NCT ID: NCT02693535
Age Range: 12+
Sex: ALL
Phase: 2
This study tests FDA-approved targeted cancer drugs in people with advanced cancers, including multiple myeloma, whose tumors have specific genetic changes that may respond to these treatments. The study is unique because it matches patients to treatments based on their tumor's genetic profile rather than just the type of cancer, which may help multiple myeloma patients find more personalized and effective treatment options.
Third Opinion AI Generated Synopsis

A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT05372354
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing CC-92480 (BMS-986348) combined with other cancer treatments in patients with multiple myeloma that has returned or stopped responding to previous therapies. The research explores new drug combinations that may provide additional treatment options for patients whose cancer has become resistant to standard therapies, including immunomodulatory drugs, proteasome inhibitors, and newer T-cell directed treatments.
Third Opinion AI Generated Synopsis

A Trial of Selinexor, Ruxolitinib and Methylprednisolone

NCT ID: NCT06225310
Age Range: N/A
Sex: ALL
Phase: 1
This study is testing a combination of three medications - Selinexor, Ruxolitinib, and Methylprednisolone - for patients with multiple myeloma that has returned or stopped responding to treatment after at least three previous therapies. The combination includes Selinexor, a first-of-its-kind oral drug that works by blocking a specific protein pathway in cancer cells, potentially offering multiple myeloma patients a new treatment approach when combined with other targeted therapies.
Third Opinion AI Generated Synopsis

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

NCT ID: NCT05243797
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing teclistamab (a targeted therapy) alone or combined with lenalidomide compared to lenalidomide alone as maintenance treatment for people with newly diagnosed multiple myeloma who have received a stem cell transplant. This research is unique because it explores whether adding teclistamab, which helps the immune system attack cancer cells, can provide better long-term control of multiple myeloma than current standard maintenance therapy.
Third Opinion AI Generated Synopsis

Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers

NCT ID: NCT06722014
Age Range: 22+
Sex: ALL
Phase: NA
This study is testing a smartphone app that combines cognitive behavioral therapy with pain medication support for patients with advanced cancer (including multiple myeloma) who have chronic pain. The app is unique because it brings together both psychological and medical approaches to pain management in one mobile tool, which could help patients better manage their cancer-related pain at home.
Third Opinion AI Generated Synopsis

Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myeloma

NCT ID: NCT06207799
Age Range: 18 - 75
Sex: ALL
Phase: 2
This study tests whether giving elranatamab (a targeted therapy) before and after an autologous stem cell transplant can help control newly diagnosed, high-risk multiple myeloma. The study uses a special approach called MRD-guided maintenance therapy, which adjusts treatment based on whether tiny amounts of cancer cells can still be detected in the body, potentially leading to more personalized and effective treatment for patients with aggressive forms of multiple myeloma.
Third Opinion AI Generated Synopsis

TriPRIL CAR T Cells in Multiple Myeloma

NCT ID: NCT05020444
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing TriPRIL CAR T cells, a modified immune cell therapy, in patients with multiple myeloma that has returned or stopped responding to previous treatments. This treatment is unique because it uses the patient's own immune cells that are genetically modified to better recognize and attack multiple myeloma cancer cells, potentially offering a new treatment option when standard therapies are no longer effective.
Third Opinion AI Generated Synopsis

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

NCT ID: NCT04771572
Age Range: 13+
Sex: ALL
Phase: 1
This study is testing LP-118, an oral medication, in patients with relapsed or refractory blood cancers including Multiple Myeloma, leukemia, lymphoma, and other blood disorders. The research aims to find the safest dose of LP-118 and may offer a new treatment option for Multiple Myeloma patients who have tried standard therapies like proteasome inhibitors, immunomodulatory drugs, and anti-CD38 treatments without success.
Third Opinion AI Generated Synopsis

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

NCT ID: NCT06340646
Age Range: 18+
Sex: ALL
Phase: NA
This study examines how cancer patients and survivors, including those with multiple myeloma, can be given choices about what types of genetic test results they want to receive from their cancer research participation. The research focuses on understanding how giving patients control over their genetic information affects their knowledge, expectations, and satisfaction with their cancer care experience.
Third Opinion AI Generated Synopsis

A Study of GC012F (AZD0120), a CAR T Therapy Targeting CD19 and BCMA in Early-Line Treatment in Subjects With Multiple Myeloma

NCT ID: NCT07073547
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing GC012F (AZD0120), a CAR T-cell therapy that targets both CD19 and BCMA proteins, in patients with newly diagnosed or early relapsed/refractory multiple myeloma who have received limited prior treatments. This treatment is unique because it simultaneously attacks two different targets on cancer cells, which may help prevent the cancer from becoming resistant and could provide better outcomes for patients in earlier stages of their disease.
Third Opinion AI Generated Synopsis

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

NCT ID: NCT01962636
Age Range: 55-
Sex: ALL
Phase: NA
This study tests umbilical cord blood transplantation combined with chemotherapy drugs and radiation for patients with blood cancers including multiple myeloma, leukemias, and lymphomas. The treatment uses a powerful preparative regimen that destroys diseased bone marrow before transplanting healthy cord blood stem cells, which may offer hope for patients with high-risk blood cancers who need intensive treatment to achieve long-term remission.
Third Opinion AI Generated Synopsis

Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

NCT ID: NCT04614558
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing isatuximab, a medication already approved for multiple myeloma, in patients with monoclonal gammopathy of renal significance (MGRS), a rare condition where abnormal proteins damage the kidneys. What makes this study unique is that it explores whether a cancer treatment can help restore kidney function in MGRS patients, potentially offering a new treatment option for this difficult-to-treat kidney disease.
Third Opinion AI Generated Synopsis

Coping Skills Training for Symptom Management and Daily Steps (Step Up)

NCT ID: NCT06575712
Age Range: 18 - 99
Sex: ALL
Phase: NA
This study is testing a program called "Step Up" that combines coping skills training and activity coaching for people with blood cancers like multiple myeloma who have received stem cell transplants or CAR-T cell therapy. The program uses both in-person sessions and mobile health technology to help patients better manage symptoms like pain, fatigue, and stress, which may improve their ability to stay physically active and reduce disability.
Third Opinion AI Generated Synopsis

A Study of Daratumumab

NCT ID: NCT05438043
Age Range: N/A
Sex: ALL
Phase: 3
This study provides continued access to daratumumab treatment for patients with multiple myeloma or smoldering multiple myeloma who are already benefiting from this medication in previous clinical trials. This extension study is unique because it allows patients to keep receiving effective treatment even after their original study has ended, potentially providing ongoing cancer control and quality of life benefits.
Third Opinion AI Generated Synopsis

A Study to Investigate the Safety and Efficacy of SAR446523 Injected Subcutaneously in Adult Participants With Relapsed/Refractory Myeloma

NCT ID: NCT06630806
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new injectable treatment called SAR4465523 given under the skin for adults with multiple myeloma that has returned or stopped responding to previous treatments. The study is unique because it is the first time this treatment is being tested in humans, and it may offer a new treatment option for multiple myeloma patients who have already tried at least three other therapies.
Third Opinion AI Generated Synopsis

Personalized NK Cell Therapy in CBT

NCT ID: NCT02727803
Age Range: 15 - 80
Sex: ALL
Phase: 2
This study tests personalized natural killer (NK) cell therapy given after chemotherapy and umbilical cord blood transplant in patients with blood cancers including multiple myeloma, leukemia, lymphoma, and myelodysplastic syndromes. The treatment uses a personalized approach by matching donor cord blood to each patient's specific immune markers (HLA and KIR typing) to optimize the NK cells' ability to fight remaining cancer cells and reduce transplant complications.
Third Opinion AI Generated Synopsis

Belantamab Mafodotin and Lenalidomide for the Treatment of Multiple Myeloma in Patients With Minimal Residual Disease Positive After Stem Cell Transplant

NCT ID: NCT04876248
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of belantamab mafodotin (a targeted therapy that delivers chemotherapy directly to cancer cells) and lenalidomide in multiple myeloma patients who still have detectable cancer cells after stem cell transplant. The goal is to determine if this treatment combination can eliminate remaining cancer cells and help patients achieve a deeper response, potentially improving long-term outcomes.
Third Opinion AI Generated Synopsis

Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma

NCT ID: NCT05789303
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of four cancer medicines (belantamab mafodotin, carfilzomib, pomalidomide, and dexamethasone) for patients with multiple myeloma that has returned or gotten worse after previous treatments, including CAR-T cell therapy. This research is unique because it combines a newer targeted therapy with established multiple myeloma drugs to potentially offer another treatment option for patients whose cancer has not responded to standard therapies.
Third Opinion AI Generated Synopsis

APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies

NCT ID: NCT03537482
Age Range: 18+
Sex: ALL
Phase: Early 1
This study is testing a new drug called APG-2575 in patients with blood cancers, including multiple myeloma, who have not responded to standard treatments or cannot receive them. APG-2575 works differently than current treatments by targeting specific proteins in cancer cells, which may offer a new treatment option for patients whose cancer has stopped responding to other therapies.
Third Opinion AI Generated Synopsis

Hypofractionation (Radiation) Trial for Multiple Myeloma

NCT ID: NCT06270888
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a shorter, more intense radiation treatment schedule (called hypofractionation) for patients with multiple myeloma who need radiation therapy for their bone lesions. Instead of the usual 2-3 weeks of radiation treatments, this approach delivers higher daily doses over fewer days, which could provide the same benefits while reducing the time patients spend receiving treatment.
Third Opinion AI Generated Synopsis

Alternate Doses and Dosing Schedules of Belantamab Mafodotin for Treatment of Triple-Class Refractory Multiple Myeloma

NCT ID: NCT05847569
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing different doses and schedules of belantamab mafodotin, a targeted therapy that delivers chemotherapy directly to cancer cells, for patients with multiple myeloma that has returned or stopped responding to three different types of standard treatments. The research aims to find better dosing approaches that may reduce side effects like eye problems while still effectively treating this hard-to-treat form of multiple myeloma.
Third Opinion AI Generated Synopsis

Iberdomide Versus Observation Off Therapy After Idecabtagene Vicleucel CAR-T for Multiple Myeloma

NCT ID: NCT06179888
Age Range: 18+
Sex: ALL
Phase: 2
This study compares iberdomide maintenance therapy to observation (monitoring without treatment) in multiple myeloma patients who have received CAR-T cell therapy with idecabtagene vicleucel. This research is unique because it tests whether continuing treatment with iberdomide after CAR-T therapy can help keep multiple myeloma under control longer and potentially extend survival compared to the standard approach of just monitoring patients.
Third Opinion AI Generated Synopsis

Post-Op Pain Control for Prophylactic Intramedullary Nailing.

NCT ID: NCT03823534
Age Range: 18+
Sex: ALL
Phase: 3
This study compares different pain control methods for patients with bone tumors from multiple myeloma, lymphoma, or bone metastases who are having preventive surgery to place a metal rod in their thigh bone. The research tests whether adding toradol (a non-opioid pain medication) to standard opioid pain medicines can reduce the need for opioids after surgery, which could help address opioid dependency concerns while still providing effective pain relief.
Third Opinion AI Generated Synopsis

VitD3 Supplementation in Patients With Multiple Myeloma

NCT ID: NCT05846880
Age Range: 18+
Sex: ALL
Phase: Early 1
This study examines vitamin D supplementation combined with lenalidomide maintenance therapy for multiple myeloma patients who have received stem cell transplants. The research uniquely focuses on how vitamin D may enhance immune system recovery after transplant and potentially improve long-term disease control, offering insights into a simple nutritional approach that could benefit patient outcomes.
Third Opinion AI Generated Synopsis

ON 123300 (Narazaciclib) and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT06351644
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests the combination of ON 123300 (Narazaciclib), a new oral cancer drug, with dexamethasone in patients with multiple myeloma that has returned or stopped responding to previous treatments. This research is unique because ON 123300 is the first drug in its class to block specific proteins (CDK4 and ARK5) that help cancer cells grow, potentially offering a new treatment option for multiple myeloma patients who have already tried other therapies.
Third Opinion AI Generated Synopsis

A Study of Talquetamab for People with Multiple Myeloma Who Have Received BCMA CAR T-Cell Therapy

NCT ID: NCT06066346
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing talquetamab, a targeted therapy, for people with multiple myeloma whose cancer has returned or stopped responding to treatment after receiving BCMA CAR T-cell therapy. The research focuses on finding effective treatment options specifically for patients who have already tried this advanced immunotherapy, potentially offering a new approach when CAR T-cell therapy is no longer working.
Third Opinion AI Generated Synopsis

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

NCT ID: NCT04566328
Age Range: 18+
Sex: ALL
Phase: 3
This study is testing whether adding bortezomib to a three-drug combination (daratumumab, lenalidomide, and dexamethasone) works better than the three drugs alone for treating adults with newly diagnosed multiple myeloma. This research focuses specifically on patients with standard-risk disease and uses advanced genetic testing to personalize treatment, which may help doctors choose the most effective therapy for each patient's specific type of multiple myeloma.
Third Opinion AI Generated Synopsis

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of BMS-986393 in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT06121843
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing BMS-986393 combined with three other cancer drugs (alnutumab, mezigdomide, and iberdomide) in patients with multiple myeloma that has returned or stopped responding to previous treatments. The research focuses on finding safe and effective drug combinations that could provide new treatment options for patients whose cancer has become difficult to treat with standard therapies.
Third Opinion AI Generated Synopsis

Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Stem Cell Transplantation

NCT ID: NCT05135351
Age Range: 19+
Sex: ALL
Phase: NA
This study tests whether taking prebiotic supplements (resistant starch) can improve gut bacteria health in patients with multiple myeloma or lymphoma who are receiving an autologous stem cell transplant. The research is unique because it focuses on supporting the gut's beneficial bacteria during transplant recovery, which may lead to better survival outcomes for patients undergoing this important cancer treatment.
Third Opinion AI Generated Synopsis

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT06153251
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a new treatment called BMS-986453, given along with fludarabine and cyclophosphamide, in patients with multiple myeloma that has returned or stopped responding to previous treatments. The treatment uses a unique approach that may help the immune system better fight cancer cells, potentially offering a new option for patients whose multiple myeloma has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

Tumor-Associated Antigen-Specific Cytotoxic T-Lymphocytes for Multiple Myeloma

NCT ID: NCT02291848
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a new treatment using specially trained immune cells called tumor-associated antigen-specific cytotoxic T-lymphocytes (TAA-specific CTLs) for patients with multiple myeloma or early-stage blood disorders that may develop into multiple myeloma. The treatment uses the patient's own immune cells that are modified in the laboratory to better recognize and attack five specific proteins found on cancer cells, potentially offering a personalized approach to prevent disease progression or treat existing multiple myeloma.
Third Opinion AI Generated Synopsis

A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

NCT ID: NCT05137054
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing linvoseltamab, an experimental drug, combined with other cancer treatments for adults with multiple myeloma (a blood cancer) that no longer responds to standard treatments. This is the first time linvoseltamab will be studied in combination with other therapies, which may provide new treatment options for patients whose cancer has become resistant to current medications.
Third Opinion AI Generated Synopsis

A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

NCT ID: NCT06679101
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two different combination treatments for people with newly diagnosed multiple myeloma who cannot receive a stem cell transplant due to age, other health conditions, or personal choice. The research tests whether adding belantamab mafodotin to lenalidomide and dexamethasone works better than the current standard combination of daratumumab, lenalidomide, and dexamethasone to help patients live longer without their cancer getting worse.
Third Opinion AI Generated Synopsis

Prehabilitation Feasibility Among Older Adults Undergoing Transplantation

NCT ID: NCT05642884
Age Range: 60+
Sex: ALL
Phase: NA
This study is testing whether a prehabilitation program that includes exercise and dietary guidance can help older adults (60 years and older) with Multiple Myeloma who are scheduled to receive an autologous stem cell transplant. The research aims to determine if preparing patients with structured physical activity and nutrition support before their transplant can improve their physical function and recovery compared to standard care.
Third Opinion AI Generated Synopsis

A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM)

NCT ID: NCT06055894
Age Range: 18+
Sex: ALL
Phase: NA
This study examines how a plant-based diet and dietary supplements (omega-3, curcumin, or probiotics) affect gut health in people with smoldering multiple myeloma, a precancerous condition that may develop into active multiple myeloma. The research focuses on measuring changes in butyrate levels in stool samples, which could help scientists understand how dietary interventions might influence disease progression and overall health in multiple myeloma patients.
Third Opinion AI Generated Synopsis

LMY-920 for Treatment of Relapsed or Refractory Myeloma

NCT ID: NCT05546723
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing LMY-920, a new type of CAR-T cell therapy that targets the BAFF ligand, for patients with multiple myeloma that has returned or stopped responding to at least three previous treatments. This approach offers a potential new treatment option for patients whose cancer may have become resistant to other CAR-T therapies, including those targeting BCMA, by using a different target on the cancer cells.
Third Opinion AI Generated Synopsis

Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma

NCT ID: NCT04680468
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing belantamab mafodotin, a targeted antibody-drug treatment, in multiple myeloma patients who are receiving stem cell transplants and maintenance therapy. The research uniquely combines this new treatment with standard transplant procedures and ongoing maintenance care to potentially improve outcomes for patients with multiple myeloma.
Third Opinion AI Generated Synopsis

COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide

NCT ID: NCT05434689
Age Range: 19+
Sex: ALL
Phase: 1, 2
This study tests combination treatments using iberdomide along with other cancer drugs for multiple myeloma patients who still have detectable cancer cells after stem cell transplant. The goal is to eliminate remaining cancer cells (minimal residual disease) that standard treatments couldn't remove, which may help prevent the cancer from returning and improve long-term outcomes for patients.
Third Opinion AI Generated Synopsis

Cevostamab Following CAR T Cell Therapy for RRMM

NCT ID: NCT05801939
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether cevostamab, a targeted immunotherapy drug, can improve treatment outcomes when given after CAR T-cell therapy in patients with relapsed or refractory multiple myeloma. The research aims to determine if adding cevostamab as a follow-up treatment can increase the number of patients who achieve complete remission with no detectable cancer cells, potentially offering a new approach to extend and deepen responses after CAR T-cell therapy.
Third Opinion AI Generated Synopsis

A Phase III Randomized Trial Comparing Stereotactic Body Radiation Therapy (SBRT) vs Conventional Palliative Radiation Therapy for Painful Bone Metastases

NCT ID: NCT06065449
Age Range: 18+
Sex: ALL
Phase: 3
This study compares stereotactic body radiation therapy (SBRT), a highly precise form of radiation treatment, against standard radiation therapy for patients with painful bone metastases (cancer that has spread to the bones). SBRT delivers focused, high-dose radiation beams with extreme accuracy, potentially providing better pain relief while reducing side effects compared to conventional radiation approaches.
Third Opinion AI Generated Synopsis

A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)

NCT ID: NCT05519085
Age Range: 18+
Sex: ALL
Phase: 3
This study compares two different drug combinations for treating patients with relapsed or refractory multiple myeloma who have received 1-3 previous treatments and were previously treated with lenalidomide: one combination uses mezigdomide with bortezomib and dexamethasone, while the other uses pomalidomide with bortezomib and dexamethasone. This research is important because it tests whether mezigdomide, a newer medication, can provide better treatment outcomes than the current standard combination for multiple myeloma patients whose cancer has returned or stopped responding to treatment.
Third Opinion AI Generated Synopsis

Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial

NCT ID: NCT05497804
Age Range: 18 - 80
Sex: ALL
Phase: 2
This study tests a combination of four cancer medicines (carfilzomib, daratumumab, lenalidomide, and dexamethasone) in patients with newly diagnosed high-risk multiple myeloma. The study focuses on determining if patients who have very small amounts of cancer remaining after initial treatment, called minimal residual disease, will benefit from this four-drug combination approach.
Third Opinion AI Generated Synopsis

ATRA and Carfilzomib in Plasma Cell Myeloma Patients

NCT ID: NCT06536413
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study tests a combination of ATRA (a vitamin A-based drug) and carfilzomib in patients with multiple myeloma whose cancer has not responded to or has returned after previous treatments, including proteasome inhibitors. The research aims to determine if adding ATRA can make carfilzomib more effective against cancer cells that have become resistant to standard proteasome inhibitor treatments.
Third Opinion AI Generated Synopsis

Iberdomide Alone or in Combination with Dexamethasone for the Treatment of Intermediate- or High-Risk Smoldering Multiple Myeloma

NCT ID: NCT04776395
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether iberdomide, an immune system medication, works alone or combined with dexamethasone to treat patients with intermediate- or high-risk smoldering multiple myeloma (a pre-cancer blood condition). The research aims to determine if this treatment can delay progression to active cancer while being well-tolerated, potentially offering patients a way to prevent their condition from becoming symptomatic multiple myeloma.
Third Opinion AI Generated Synopsis

Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma

NCT ID: NCT04756726
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing cemsidomidc (CFT7455), a new oral medication given alone or with dexamethasone, in patients with multiple myeloma or non-Hodgkin's lymphoma that has not responded to previous treatments. The study aims to find the safest and most effective dose of this experimental drug, which could provide a new treatment option for patients whose cancer has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

Impact of Recombinant Human Interleukin-7 (CYT107) on Tumor Clearance and Immune Reconstitution in Multiple Myeloma Patients After Autologous Hematopoietic Cell Transplant

NCT ID: NCT06523699
Age Range: 18+
Sex: ALL
Phase: 1
This study tests whether adding a laboratory-made protein called CYT107 (interleukin-7) to standard stem cell transplant treatment can help multiple myeloma patients recover their immune system and fight cancer cells more effectively. The treatment aims to boost the body's T-cells, which are important immune cells that help destroy cancer and prevent infections after transplant.
Third Opinion AI Generated Synopsis

A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

NCT ID: NCT06215118
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a combination of two cancer drugs, elranatemab and iberdomide, in patients with multiple myeloma (a blood cancer) that has returned or stopped responding to previous treatments. The research aims to find the safest and most effective dose of this drug combination, which could provide a new treatment option for patients whose cancer has been difficult to control with standard therapies.
Third Opinion AI Generated Synopsis

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05730036
Age Range: 18+
Sex: ALL
Phase: 3

This study is testing a new cancer drug called linvoselutamab compared to a combination of three standard drugs (elotuzumab, pomalidomide, and dexamethasone) in adults with multiple myeloma that has returned or stopped responding to previous treatments. This research is unique because it compares a single experimental drug that works differently than current treatments to a proven three-drug combination, which could potentially offer patients a simpler treatment option with similar or better results for controlling their cancer.

Third Opinion AI Generated Synopsis

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

NCT ID: NCT06208150
Age Range: 18+
Sex: ALL
Phase: 3
This study compares different combinations of cancer medicines, including talquetamab with pomalidomide or teclistamab, against standard treatment combinations for patients with multiple myeloma that has returned or stopped responding to previous treatments, specifically those who have already received anti-CD38 antibody therapy and lenalidomide. This research is unique because it tests newer targeted therapies that work differently than conventional treatments, potentially offering patients with hard-to-treat multiple myeloma more effective treatment options when their cancer has become resistant to standard medicines.
Third Opinion AI Generated Synopsis

The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

NCT ID: NCT05436418
Age Range: 12+
Sex: ALL
Phase: 1, 2
This study tests whether a lower dose of cyclophosphamide medication, combined with other drugs, can better prevent graft-versus-host disease in patients with blood cancers who receive stem cell transplants from donors. The research aims to find the safest and most effective dose combination that reduces transplant complications while maintaining the cancer-fighting benefits of the donor cells.
Third Opinion AI Generated Synopsis

Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM

NCT ID: NCT04653246
Age Range: 75+
Sex: ALL
Phase: 2
This study is testing a combination treatment that includes isatuximab (an investigational drug) along with lenalidomide, bortezomib, and dexamethasone for patients with newly diagnosed multiple myeloma. This research is unique because it combines a newer targeted therapy with established standard treatments to potentially improve outcomes for patients who have just been diagnosed with this blood cancer.
Third Opinion AI Generated Synopsis

Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

NCT ID: NCT05327023
Age Range: 12 - 120
Sex: ALL
Phase: 1, 2
This study is testing whether giving patients an infusion of immune cells (lymphocytes) from their bone marrow donor after transplant can help reduce the chance of blood cancer returning in people with high-risk blood cancers like multiple myeloma, leukemia, and lymphoma. This approach is unique because it adds the donor's infection-fighting cells one week after transplant to boost the body's ability to fight any remaining cancer cells, potentially offering better long-term cancer control for patients with aggressive blood cancers.
Third Opinion AI Generated Synopsis

A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT04634552
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing a new cancer treatment called talquetamab in patients with multiple myeloma that has either come back after treatment or has not responded to previous therapies. The research focuses on evaluating how well this treatment works and how safe it is for patients whose cancer has been difficult to treat with standard approaches.
Third Opinion AI Generated Synopsis

Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myeloma

NCT ID: NCT05391750
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing a combination of two drugs, venetoclax and tocilizumab, in patients with a specific type of multiple myeloma called t(11;14) that has returned after treatment or stopped responding to previous therapies. This research is unique because it combines venetoclax, which targets a protein that helps cancer cells survive, with tocilizumab, which may help control side effects from immune therapy while also interfering with tumor growth, potentially offering a new treatment approach for patients with this challenging form of multiple myeloma.
Third Opinion AI Generated Synopsis

Free from Maintenance Drug Therapy in Multiple Myeloma (The FREEDMM Trial) for Minimal Residual Disease (MRD

NCT ID: NCT05192122
Age Range: 18+
Sex: ALL
Phase: 1
This study examines whether multiple myeloma patients who have achieved very good partial response or complete response after stem cell transplant can safely stop their maintenance therapy. The research aims to determine if patients with no detectable cancer cells can remain in remission without continuing long-term maintenance treatment, potentially reducing side effects and improving quality of life.
Third Opinion AI Generated Synopsis

Study of ABBV-383 Assessing Adverse Events and Clinical Activity With Subcutaneous (SC) Injection in Adult Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06223516
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing ABBV-383, an investigational drug given by injection under the skin or through an IV, in adults with multiple myeloma that has returned or stopped responding to previous treatments. The research is unique because it examines a new targeted therapy that may offer hope for patients whose cancer has not improved with standard treatments including proteasome inhibitors, anti-CD38 antibodies, and immunomodulatory drugs.
Third Opinion AI Generated Synopsis

MC210808 Venetoclax in Combination With Lenalidomide and Dexamethasone (Ven-Rd), Daratumumab and Dexamethasone (Ven-Dd), or Daratumumab-Lenalidomide-Dexamethasone (Ven-DRd) for the Treatment of Multiple Myeloma

NCT ID: NCT06042725
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing venetoclax combined with standard multiple myeloma treatments (lenalidomide, dexamethasone, and daratumumab) in patients with multiple myeloma that has a specific genetic marker called t(11;14). The study focuses on finding the safest doses of these drug combinations and may offer better cancer control than current treatments by targeting multiple pathways that help myeloma cells survive.
Third Opinion AI Generated Synopsis

Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma

NCT ID: NCT05363111
Age Range: 18+
Sex: ALL
Phase: 1
This study tests a combination of radioimmunotherapy treatments (daratumumab with radioactive tracers indium-111 and actinium-225) for patients with multiple myeloma that has returned or stopped responding to previous treatments. The unique approach combines a targeted antibody therapy with radioactive substances to deliver radiation directly to cancer cells, potentially offering a new treatment option for patients who have already tried standard therapies including proteasome inhibitors, immunomodulatory drugs, and anti-CD38 antibodies.
Third Opinion AI Generated Synopsis

Nivolumab in Multiple Myeloma Patients After Idecabtagene Vicleucel

NCT ID: NCT06523621
Age Range: 18+
Sex: ALL
Phase: 2
This study tests whether nivolumab, an immunotherapy drug, can improve treatment responses in multiple myeloma patients who had a partial response to idecabtagene vicleucel (a CAR-T cell therapy). The research aims to determine if adding nivolumab after CAR-T therapy can help deepen the cancer response and potentially provide better outcomes for patients with relapsed or treatment-resistant multiple myeloma.
Third Opinion AI Generated Synopsis

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

NCT ID: NCT04975555
Age Range: 18+
Sex: ALL
Phase: 2
This study tests siltuximab, a medication that may help reduce serious side effects called cytokine release syndrome and brain-related complications that can occur when patients with blood cancers including multiple myeloma receive CAR-T cell therapy. The research aims to make CAR-T cell treatment safer by preventing or lessening these potentially dangerous side effects, which could help more multiple myeloma patients benefit from this advanced cancer treatment.
Third Opinion AI Generated Synopsis

Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial

NCT ID: NCT05514990
Age Range: 18+
Sex: ALL
Phase: 1, 2
This study is testing a combination of cancer drugs (bortezomib, pembrolizumab, and dexamethasone) with or without an experimental virus treatment (pelareoreb) for patients with multiple myeloma that has returned or stopped responding to at least three previous treatments. This research is unique because it combines a laboratory-modified virus that can kill cancer cells with standard cancer treatments and immunotherapy, which may offer a new treatment option for patients whose multiple myeloma is difficult to treat.
Third Opinion AI Generated Synopsis

Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma

NCT ID: NCT06465316
Age Range: 18+
Sex: ALL
Phase: 1
This study tests the combination of iberdomide and teclistamab (TECVAYLI) as a treatment for patients with multiple myeloma that has returned after treatment or is not responding to current therapies. The study is unique because it combines two different types of cancer-fighting drugs - one that helps the immune system attack cancer cells and another that destroys proteins cancer cells need to survive - which may provide a safer and more effective treatment option for patients with hard-to-treat multiple myeloma.
Third Opinion AI Generated Synopsis

Post-Transplant Maintenance Therapy With Isatuximab Plus Lenalidomide for High-Risk Multiple Myeloma Patients

NCT ID: NCT05776979
Age Range: 18 - 72
Sex: ALL
Phase: 2

This study tests a combination of isatuximab and lenalidomide as maintenance therapy for patients with high-risk multiple myeloma who have already received a stem cell transplant. The research aims to determine if this dual-drug approach can better control the cancer and prevent it from returning compared to standard maintenance treatments alone.

Third Opinion AI Generated Synopsis

Isatuximab, Pomalidomide, Elotuzumab and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma

NCT ID: NCT04835129
Age Range: 18+
Sex: ALL
Phase: 2
This study tests a combination of four cancer drugs (isatuximab, pomalidomide, elotuzumab, and dexamethasone) in patients with multiple myeloma that has returned or stopped responding to at least two previous treatments. This research is unique because it combines multiple targeted therapies that work through different mechanisms, which may provide better disease control and potentially improve outcomes for patients whose cancer has become resistant to standard treatments.
Third Opinion AI Generated Synopsis

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

NCT ID: NCT06140524
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing whether linvoselimab, an investigational drug, can safely eliminate abnormal plasma cells in adults with high-risk monoclonal gammopathy of undetermined significance (HR-MGUS) or non-high-risk smoldering multiple myeloma (NHR-SMM), which are conditions that may develop into multiple myeloma. This research is unique because it aims to prevent progression to active multiple myeloma by targeting and removing abnormal cells before they cause symptoms, potentially offering patients a way to avoid developing full multiple myeloma.
Third Opinion AI Generated Synopsis

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

NCT ID: NCT06059391
Age Range: 18 - 75
Sex: ALL
Phase: 2
This study tests how well a CMV vaccine given to stem cell donors protects patients with blood cancers (like leukemia and lymphoma) from cytomegalovirus (CMV) infection after receiving a stem cell transplant from a related family member. What makes this approach unique is that the donors receive the vaccine before donation, allowing them to transfer protective immunity to the patient through the transplanted stem cells, which could reduce serious CMV complications that often occur after transplant.
Third Opinion AI Generated Synopsis

Study to Assess Allogeneic Anti-CD38 A2 Dimeric Antigen Receptor T Cells in Relapsed or Refractory Multiple Myeloma

NCT ID: NCT05007418
Age Range: 18+
Sex: ALL
Phase: 1
This study tests STI-1492, a specially designed immune cell therapy that uses modified T-cells from healthy donors to target CD38 proteins on cancer cells, in patients with multiple myeloma that has returned or stopped responding to previous treatments. This approach is unique because it uses donor immune cells that have been engineered to better recognize and attack myeloma cells, potentially offering a new treatment option for patients whose cancer has become resistant to standard therapies.
Third Opinion AI Generated Synopsis

P-BCMA-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Multiple Myeloma

NCT ID: NCT04960579
Age Range: 18+
Sex: ALL
Phase: 1
This study is testing P-BCMA-ALLO1 CAR-T cell therapy, which uses immune cells from donors to fight multiple myeloma in patients whose cancer has returned or stopped responding to previous treatments. What makes this treatment unique is that it uses donor immune cells instead of the patient's own cells, which could make the therapy faster to prepare and potentially available to more patients who need treatment.
Third Opinion AI Generated Synopsis

A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

NCT ID: NCT05572515
Age Range: 18+
Sex: ALL
Phase: 3
This study compares teclistamab (a single drug treatment) with standard combination treatments in adults with multiple myeloma that has returned or stopped responding to previous therapies. The study is unique because it tests whether teclistamab alone can work as well as or better than current standard treatments, which could offer patients a simpler treatment option with potentially fewer side effects.
Third Opinion AI Generated Synopsis

PUL-042 Treatment in Patients With Parainfluenza Virus (PIV), Human Metapneumovirus (hMPV) or Respiratory Syncytial Virus (RSV)

NCT ID: NCT06665100
Age Range: 18+
Sex: ALL
Phase: 2
This study is testing an inhaled experimental drug called PUL-042 in patients with blood cancers (including multiple myeloma) or stem cell transplant recipients who have developed lung infections caused by specific respiratory viruses. What makes this study unique is that PUL-042 is designed to reduce the severity of viral lung infections in patients with weakened immune systems, potentially offering a new treatment option for these high-risk patients who are more vulnerable to serious respiratory complications.
Third Opinion AI Generated Synopsis

Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM)

NCT ID: NCT06057402
Age Range: 18+
Sex: ALL
Phase: 4
This study provides continued access to elranatamab treatment for multiple myeloma patients who were already receiving this medication in previous clinical trials and are still benefiting from it. This post-trial access study is unique because it allows patients to keep receiving a potentially effective treatment that might not otherwise be available to them after their original study ended.
Third Opinion AI Generated Synopsis